Recombinant Human FLT3 Protein, GMP Grade, Animal-Free
Cat.No. : | FLT3-29HG |
Product Overview : | GMP Recombinant Human FLT3 protein with out tag was expressed in E. coli and manufactured using animal-derived component free materials. |
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Description : | Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. |
Source : | E. coli |
Species : | Human |
AA Sequence : | MTQDCSFQHSPISSDFAVKIRELSD YLLQDYPVTVASNLQDEELCGGLWR LVLAQRWMERLKTVAGSKMQGLLER VNTEIHFVTKCAFQPPPSCLRFVQT NISRLLQETSEQLVALKPWITRQNF SRCLELQCQPDSSTLPPPWSPRPLE ATAPTA |
Purity : | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Gene Name : | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2; |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
MIM : | 136351 |
UniProt ID : | P36888 |
Products Types
◆ Recombinant Protein | ||
Flt3-3045M | Recombinant Mouse Flt3 Protein, Myc/DDK-tagged | +Inquiry |
FLT3-1507C | Recombinant Cynomolgus FLT3 protein, hFc-tagged | +Inquiry |
FLT3-6334H | Recombinant Human FLT3 protein, His-tagged | +Inquiry |
FLT3-98P | Active Recombinant Porcine FLT-3 Ligand Protein | +Inquiry |
FLT3-4543H | Recombinant Human FLT3 protein, His-tagged | +Inquiry |
◆ Lysates | ||
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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