| Description : |
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
112.7 kDa |
| AA Sequence : |
MPALARGGGQLPLLVVFSAMIFGTI TNQDLPVIKCVLINHKNNDSSVGKS SSYPMVSESPEDLGCALRPQSSGTV YEAAAVEVDVSASITLQVLVDAPGN ISCLWVFKHSSLNCQPHFDLQNRGV VSMVILKMTETQAGEYLLFIQSEAT NYTILFTVSIRNTLLYTLRRPYFRK MENQDALVCISESVPEPIVEWVLCD SQGESCKEESPAVVKKEEKVLHELF GMDIRCCARNELGRECTRLFTIDLN QTPQTTLPQLFLKVGEPLWIRCKAV HVNHGFGLTWELENKALEEGNYFEM STYSTNRTMIRILFAFVSSVARNDT GYYTCSSSKHPSQSALVTIVEKGFI NATNSSEDYEIDQYEEFCFSVRFKA YPQIRCTWTFSRKSFPCEQKGLDNG YSISKFCNHKHQPGEYIFHAENDDA QFTKMFTLNIRRKPQVLAEASASQA SCFSDGYPLPSWTWKKCSDKSPNCT EEITEGVWNRKANRKVFGQWVSSST LNMSEAIKGFLVKCCAYNSLGTSCE TILLNSPGPFPFIQDNISFYATIGV CLLFIVVLTLLICHKYKKQFRYESQ LQMVQVTGSSDNEYFYVDFREYEYD LKWEFPRENLEFGKVLGSGAFGKVM NATAYGISKTGVSIQVAVKMLKEKA DSSEREALMSELKMMTQLGSHENIV NLLGACTLSGPIYLIFEYCCYGDLL NYLRSKREKFHRTWTEIFKEHNFSF YPTFQSHPNSSMPGSREVQIHPDSD QISGLHGNSFHSEDEIEYENQKRLE EEEDLNVLTFEDLLCFAYQVAKGME FLEFKSCVHRDLAARNVLVTHGKVV KICDFGLARDIMSDSNYVVRGNARL PVKWMAPESLFEGIYTIKSDVWSYG ILLWEIFSLGVNPYPGIPVDANFYK LIQNGFKMDQPFYATEEIYIIMQSC WAFDSRKRPSFPNLTSFLGCQLADA EEAMYQNVDGRVSECPHTYQNRRPF SREMDLGLLSPQAQVEDSTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
