Recombinant Human HDAC1 Protein, His/FLAG-tagged HDAC1-45H

Recombinant Human HDAC1 Protein, His/FLAG-tagged

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Recombinant Human HDAC1 Protein, His/FLAG-tagged

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Cat.No. : HDAC1-45H
Product Overview : Recombinant human HDAC1 protein with a C-terminal His/FLAG-tag was expressed in Bacmid/Sf21 cells.
Description : Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Source : Insect cells
Species : Human
Tag : His/FLAG
Molecular Mass : 57 kDa
Purity : ≥55% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC substrate 3 and HDAC1.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride and 20% glycerol
SDS-PAGE Analysis of HDAC1 :

Lane 1: MW Markers; Lane 2: HDAC1. This protein forms a complex with endogeneous Hsp 70 and is co-purified with tubulin. The identity of Hsp 70 and tubulin was confirmed by MALDITOF mass spectrometry. Representative gel image shown; actual purity may vary between each batch.

HDAC1 Deacetylase Activity :

One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC substrate 3 and HDAC1.

Gene Name : HDAC1 histone deacetylase 1 [ Homo sapiens (human) ]
Official Symbol : HDAC1
Synonyms : HDAC1; histone deacetylase 1; HD1; RPD3; KDAC1; GON-10; RPD3L1; histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1
Gene ID : 3065
mRNA Refseq : NM_004964
Protein Refseq : NP_004955
MIM : 601241
UniProt ID : Q13547

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