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Recombinant Human HDAC6 Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : HDAC6-111H
Product Overview : HDAC6 MS Standard C13 and N15-labeled recombinant protein (NP_006035) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 131.2 kDa
AA Sequence : MTSTGQDSTTTRQRRSRQNPQSPPQ DSSVTSKRNIKKGAVPRSIPNLAEV KKKGKMKKLGQAMEEDLIVGLQGMD LNLEAEALAGTGLVLDEQLNEFHCL WDDSFPEGPERLHAIKEQLIQEGLL DRCVSFQARFAEKEELMLVHSLEYI DLMETTQYMNEGELRVLADTYDSVY LHPNSYSCACLASGSVLRLVDAVLG AEIRNGMAIIRPPGHHAQHSLMDGY CMFNHVAVAARYAQQKHRIRRVLIV DWDVHHGQGTQFTFDQDPSVLYFSI HRYEQGRFWPHLKASNWSTTGFGQG QGYTINVPWNQVGMRDADYIAAFLH VLLPVALEFQPQLVLVAAGFDALQG DPKGEMAATPAGFAQLTHLLMGLAG GKLILSLEGGYNLRALAEGVSASLH TLLGDPCPMLESPGAPCRSAQASVS CALEALEPFWEVLVRSTETVERDNM EEDNVEESEEEGPWEPPVLPILTWP VLQSRTGLVYDQNMMNHCNLWDSHH PEVPQRILRIMCRLEELGLAGRCLT LTPRPATEAELLTCHSAEYVGHLRA TEKMKTRELHRESSNFDSIYICPST FACAQLATGAACRLVEAVLSGEVLN GAAVVRPPGHHAEQDAACGFCFFNS VAVAARHAQTISGHALRILIVDWDV HHGNGTQHMFEDDPSVLYVSLHRYD HGTFFPMGDEGASSQIGRAAGTGFT VNVAWNGPRMGDADYLAAWHRLVLP IAYEFNPELVLVSAGFDAARGDPLG GCQVSPEGYAHLTHLLMGLASGRII LILEGGYNLTSISESMAACTRSLLG DPPPLLTLPRPPLSGALASITETIQ VHRRYWRSLRVMKVEDREGPSSSKL VTKKAPQPAKPRLAERMTTREKKVL EAGMGKVTSASFGEESTPGQTNSET AVVALTQDQPSEAATGGATLAQTIS EAAIGGAMLGQTTSEEAVGGATPDQ TTSEETVGGAILDQTTSEDAVGGAT LGQTTSEEAVGGATLAQTTSEAAME GATLDQTTSEEAPGGTELIQTPLAS STDHQTPPTSPVQGTTPQISPSTLI GSLRTLELGSESQGASESQAPGEEN LLGEAAGGQDMADSMLMQGSRGLTD QAIFYAVTPLPWCPHLVAVCPIPAA GLDVTQPCGDCGTIQENWVCLSCYQ VYCGRYINGHMLQHHGNSGHPLVLS YIDLSAWCYYCQAYVHHQALLDVKD IAHQNKFGEDMPHPHTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]
Official Symbol : HDAC6
Synonyms : HDAC6; histone deacetylase 6; CPBHM; HD6; JM21; PPP1R90; histone deacetylase 6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6; NP_001308154.1; EC 3.5.1.98
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can HDAC6 inhibitors be used in combination with other therapies, and if so, what synergistic effects are expected? 06/19/2022

Yes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.

Are there any ongoing clinical trials targeting HDAC6, and if so, what are the potential outcomes for patients? 05/29/2020

Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.

In what other diseases has HDAC6 been implicated, and how might this knowledge be applied clinically? 12/24/2018

HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.

How does HDAC6 influence cellular processes, and why is this relevant in a clinical setting? 12/13/2017

HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.

Are there any known genetic variations in HDAC6, and how might these impact individual responses to treatments in a clinical setting? 08/22/2016

Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.

Customer Reviews (3)

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Reviews
06/23/2019

    Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

    12/07/2018

      The bands of proteins in Western Blotting experiments were very clear.

      09/16/2018

        Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

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