Recombinant Human IL13 Protein, His-tagged
|Product Overview :||Recombinant Human Interleukin-13 is produced by our Mammalian expression system and the target gene encoding Leu25-Asn146 is expressed with a 6His tag at the C-terminus.|
- Gene Information
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|Description :||Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.|
|Source :||Human Cells|
|Form :||Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4.|
|Protein Length :||Leu25-Asn146|
|AA Sequence :||LTCLGGFASPGPVPPSTALRELIEE LVNITQNQKAPLCNGSMVWSINLTA GMYCAALESLINVSGCSAIE KTQRMLSGFCPHKVS AGQFSSLHVRDTKIEVAQFVKDLLL HLKKLFREGQFNVDHHHHHH|
|Endotoxin :||Less than 0.1 ng/ug (1 EU/ug).|
|Storage :||Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
|Reconstitution :||Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Quality Statement :||Purity: Greater than 95% as determined by reducing SDS-PAGE.|
|Shipping :||The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
|Gene Name :||IL13 interleukin 13 [ Homo sapiens (human) ]|
|Official Symbol :||IL13|
|Synonyms :||Interleukin-13; IL-13; P600|
|Gene ID :||3596|
|mRNA Refseq :||NM_001354991.2|
|Protein Refseq :||NP_001341920.1|
|UniProt ID :||P35225|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Flow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)Write a review
Effective in Th2 cell differentiation. -
Good for cytokine assays. -
High yield in expression. -
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