Recombinant Human IL17A, His-tagged
Cat.No. : | IL17A-63H |
Product Overview : | Recombinant human IL17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | IL17A, also known as Interleukin 17, is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation. It is produced by T-helper cells and is induced by IL23 which results in destructive tissue damage in delayed-type reactions. This protein is a 155 amino acid protein that is a disulfide-linked, homodimeric, secreted glycoprotein with a molecular mass of 35kDa. The structure of IL17A consists of a signal peptide of 23 amino acids followed by a 123 aa chain region characteristic of the IL17 family. An N-linked glycosylation site on the protein was first identified after purification of the protein revealed two bands, one at 15kDa and another at 20kDa. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid. In phosphate buffered saline (pH 7.4) containing 20% glycerol, 1mM EDTA, 0.1mM PMSF. |
Molecular Mass : | 15.9kDa (138aa) 13.5-28kDa (SDS-PAGE under reducing conditions.) |
AA Sequence : | GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VAHHHHHH |
Endotoxin : | < 1.0 eu per 1 microgram of protein (determined by lal |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25mg/ml (determined by Bradford assay) |
Gene Name : | IL17A interleukin 17A [ Homo sapiens ] |
Official Symbol : | IL17A |
Synonyms : | IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A; |
Gene ID : | 3605 |
mRNA Refseq : | NM_002190 |
Protein Refseq : | NP_002181 |
MIM : | 603149 |
UniProt ID : | Q16552 |
Chromosome Location : | 6p12 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; |
Function : | cytokine activity; |
Products Types
◆ Recombinant Protein | ||
Il17a-253I | Active Recombinant Mouse Il17a Protein (133 aa) | +Inquiry |
IL17A-441R | Active Recombinant Rabbit IL17 Protein, His-tagged | +Inquiry |
IL17A-001C | Recombinant Cynomolgus Monkey IL17A Protein | +Inquiry |
IL17a-0022H | Recombinant Human IL17a Protein | +Inquiry |
IL17A-1008P | Recombinant Pig IL17A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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