Recombinant Human IL3RA Protein (Thr19-Arg305), C-hFc and 6×His-tagged

Cat.No. : IL3RA-556H
Product Overview : Recombinant Human IL3RA Protein (Thr19-Arg305) with C-hFc and 6×His tag was expressed in HEK293.
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Description : Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor �� chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells
Source : HEK293
Species : Human
Tag : C-hFc and 6×His
Form : Lyophilized
Molecular Mass : 80-90 kDa
Protein Length : Thr19-Arg305
Purity : > 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage : Store at -80 centigrade for 12 months (Avoid repeated freezing and thawing)
Storage Buffer : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 10 % trehalose is added as protectants before lyophilization.
SDS-PAGE:
Gene Name : IL3RA interleukin 3 receptor, alpha (low affinity) [ Homo sapiens (human) ]
Official Symbol : IL3RA
Synonyms : IL3RA; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; CD123; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform; IL3R; IL3RX; IL3RY; IL3RAY; hIL-3Ra; MGC34174;
Gene ID : 3563
mRNA Refseq : NM_002183
Protein Refseq : NP_002174
MIM : 308385
UniProt ID : P26951

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can Il3ra be personalized? 08/01/2022

The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

Does Il3ra have clinical application prospects? What are the prospects? 05/19/2022

Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

What is the action mechanism of Il3ra? 04/24/2022

Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

How is the clinical trial of Il3ra progressing? 09/16/2020

Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

What is the specific effect of Il3ra on the immune system? 08/06/2019

The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

Does Il3ra have side effects? 05/24/2019

Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.

Customer Reviews (3)

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Reviews
07/24/2022

    In special environment, good stability.

    05/25/2022

      Good crystallization property and good effect.

      06/29/2021

        Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

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