Recombinant Human Interleukin 10 Receptor, Beta
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Cat.No. : | IL10RB-1647H Optional Service: Optional requirements on this protein |
Description : | The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ) , also known as CD210b and CRF2-4, is an 80-85 kDa member of the type II cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-10 Rβ is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-85 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | IL10RB interleukin 10 receptor, beta [ Homo sapiens ] |
Synonyms : | IL10RB; erleukin 10 receptor, beta; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; cytokine receptor class-II CRF2-4; cytokine receptor family II, member 4; IL-10R-B; Interleukin-10 receptor beta chain |
Gene ID : | 3588 |
mRNA Refseq : | NM_000628 |
Protein Refseq : | NP_000619 |
MIM : | 123889 |
UniProt ID : | Q08334 |
Chromosome Location : | 21q22.1-q22.2 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Function : | interleukin-10 receptor activity; protein binding; receptor activity |
◆ Recombinant Protein
IL10RB-217H | Recombinant Human IL10RB Protein, hIgG-His-tagged | +Inquiry |
Il10rb-5180M | Recombinant Mouse Il10rb, Fc tagged | +Inquiry |
IL10RB-202H | Active Recombinant Human IL10RB, HIgG1 Fc-tagged | +Inquiry |
IL10RB-952H | Recombinant Human IL10RB Protein, Fc-tagged | +Inquiry |
IL10RB-2251H | Recombinant Human IL10RB, His tagged | +Inquiry |
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◆ Lysates
IL10RB-1371RCL | Recombinant Rat IL10RB cell lysate | +Inquiry |
IL10RB-2677HCL | Recombinant Human IL10RB cell lysate | +Inquiry |
IL10RB-1795MCL | Recombinant Mouse IL10RB cell lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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