Recombinant Human Interleukin 10 Receptor, Beta IL10RB-1647H

Recombinant Human Interleukin 10 Receptor, Beta

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Cat.No. : IL10RB-1647H Optional Service: Optional requirements on this protein
Description : The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ) , also known as CD210b and CRF2-4, is an 80-85 kDa member of the type II cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-10 Rβ is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-85 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : IL10RB interleukin 10 receptor, beta [ Homo sapiens ]
Synonyms : IL10RB; erleukin 10 receptor, beta; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; cytokine receptor class-II CRF2-4; cytokine receptor family II, member 4; IL-10R-B; Interleukin-10 receptor beta chain
Gene ID : 3588
mRNA Refseq : NM_000628
Protein Refseq : NP_000619
MIM : 123889
UniProt ID : Q08334
Chromosome Location : 21q22.1-q22.2
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : interleukin-10 receptor activity; protein binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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