Recombinant Human Interleukin 10 Receptor, Beta

• Cat.No.: IL10RB-1647H

Specification

• Cat. No.: IL10RB-1647H
• Description: The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ) , also known as CD210b and CRF2-4, is an 80-85 kDa member of the type II cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-10 Rβ is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-85 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL10RB interleukin 10 receptor, beta [ Homo sapiens ]
• Synonyms: IL10RB; erleukin 10 receptor, beta; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; cytokine receptor class-II CRF2-4; cytokine receptor family II, member 4; IL-10R-B; Interleukin-10 receptor beta chain
• Gene ID: 3588
• mRNA Refseq: NM_000628
• Protein Refseq: NP_000619
• MIM: 123889
• UniProt ID: Q08334
• Chromosome Location: 21q22.1-q22.2
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: interleukin-10 receptor activity; protein binding; receptor activity