Recombinant Human Interleukin 17A, Fc Chimera

• Cat.No.: IL17A-279H
• Product Overview: Recombinant Human Interleukin 17A is produced in mammalian cells andfused with human IgG1Fc. IL-17A (C-terminus fused with human IgG1Fc) contains 361 amino acids with predicted MW 40.82kDa x 2 (dimmer) and 12 cysteines (Fc has 6). It also has 1 N-link glycosylation site with MW increase up to 5 kDa. Receptor for IL-17A induces stromal cells to produce proinflamatory and hematopoietic cytokins. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

Specification

• Cat. No.: IL17A-279H
• Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
• Source: Mammalian cells.
• Purity: >90%.
• Quantity: 2.0mg/2ml PBS.
• Storage: -70°C

Gene Information

• Gene Name: 17A interleukin 17A [ Homo sapiens ]
• Synonyms: IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; toxic T-lymphocyte-associated antigen 8; otoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• Gene ID: 3605
• mRNA Refseq: NM_002190
• Protein Refseq: NP_002181
• MIM: 603149
• UniProt ID: Q16552
• Chromosome Location: 6p12
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity