Recombinant Human Interleukin 3 Receptor, Alpha (Low Affinity)

• Cat.No.: IL3RA-1644H

Specification

• Cat. No.: IL3RA-1644H
• Description: Interleukin 3 receptor alpha (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a type I transmembrane protein that is expressed on the large majority of progenitor cells. IL-3R alpha function can be defined by the activity of its ligand interleukin-3. IL-3 is a multipotent cytokine that promotes the development of hemopoietic progenitors into cells of the erythroid, myeloid and lymphoid lineages.1CD123 may be a promising strategy for the preferential ablation of acute myelogenous leukemia (AML) cells.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-3 sRα is Mr 33 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL3RA interleukin 3 receptor, alpha (low affinity) [ Homo sapiens ]
• Synonyms: IL3RA; interleukin 3 receptor, alpha (low affinity); RP11-261P4.2; CD123; IL3R; IL3RAY; IL3RX; IL3RY; MGC34174; hIL-3Ra; CD123 antigen; Interleukin-3 receptor; interleukin 3 receptor, alpha; IL-3R-alpha; OTTHUMP00000022828; MGC34174
• Gene ID: 3563
• mRNA Refseq: NM_002183
• Protein Refseq: NP_002174
• MIM: 308385
• UniProt ID: P26951
• Chromosome Location: Xp22.3 or Yp11.3
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Apoptosis; Hematopoietic cell lineage
• Function: interleukin-3 receptor activity; receptor activity; protein binding