Description : |
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
67.8 kDa |
AA Sequence : |
MAGNCGARGALSAHTLLFDLPPALL GELCAVLDSCDGALGWRGLAERLSS SWLDVRHIEKYVDQGKSGTRELLWS WAQKNKTIGDLLQVLQEMGHRRAIH LITNYGAVLSPSEKSYQEGGFPNIL FKETANVTVDNVLIPEHNEKGVLLK SSISFQNIIEGTRNFHKDFLIGEGE IFEVYRVEIQNLTYAVKLFKQEKKM QCKKHWKRFLSELEVLLLFHHPNIL ELAAYFTETEKFCLIYPYMRNGTLF DRLQCVGDTAPLPWHIRIGILIGIS KAIHYLHNVQPCSVICGSISSANIL LDDQFQPKLTDFAMAHFRSHLEHQS CTINMTSSSSKHLWYMPEEYIRQGK LSIKTDVYSFGIVIMEVLTGCRVVL DDPKHIQLRDLLRELMEKRGLDSCL SFLDKKVPPCPRNFSAKLFCLAGRC AATRAKLRPSMDEVLNTLESTQASL YFAEDPPTSLKSFRCPSPLFLENVP SIPVEDDESQNNNLLPSDEGLRIDR MTQKTPFECSQSEVMFLSLDKKPES KRNEEACNMPSSSCEESWFPKYIVP SQDLRPYKVNIDPSSEAPGHSCRSR PVESSCSSKFSWDEYEQYKKETRTR PLEQKLISEEDLAANDILDYKDDDD KV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |