Active Recombinant Human MERTK protein, Fc-tagged
Cat.No. : | MERTK-150H |
Product Overview : | Recombinant Human MERTK(Arg26 - Ala499) fused with Fc of Human IgG1 at C-terminal was expressed in Mouse NS0 Cells. |
- Specification
- Gene Information
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Source : | Insect cells |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Arg26 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized rhMer/Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 with a linear range of 0.03-1 µg/mL. |
Molecular Mass : | Predicted Molecular Mass: 78.9 (monomer) kDa; SDS-PAGE: 100-110 kDa, reducing conditions. |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Storage : | Avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Gene Name : | MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ] |
Official Symbol : | MERTK |
Synonyms : | MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349; |
Gene ID : | 10461 |
mRNA Refseq : | NM_006343 |
Protein Refseq : | NP_006334 |
MIM : | 604705 |
UniProt ID : | Q12866 |
Chromosome Location : | 2q14.1 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.
The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.
MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.
MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.
Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.
Customer Reviews (3)
Write a reviewFast shipping and excellent service. This product is a lab essential.
Highly recommend for quality and prompt delivery.
Exceptional product, outstanding customer service!
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