Active Recombinant Human NTF3(139-257aa)

• Cat.No.: NTF3-011H
• Product Overview: Human NTF3 (P20783, 139 a.a. - 257 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Protein Length: 139-257 a.a.
• Description: Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF.
• Theoretical MW (kDa): 14
• Form: Lyophilized
• Preparation Method: E. coli expression system
• Purity: > 97% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The ED50 was determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 10-50 ng/mL.
• Application: SDS-PAGE
• Storage: Store at -20°C on dry atmosphere for 2 years.After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P20783
• Pathways: Neurotrophin signaling pathway; MAPK signaling pathway

Gene Information

• Gene Name: NTF3 neurotrophin 3 [ Homo sapiens ]
• Official Symbol: NTF3
• Synonyms: NTF3; neurotrophin 3; NT3; HDNF; NGF2; NGF-2; MGC129711; neurotrophin-3; NT-3; OTTHUMP00000239132; OTTHUMP00000239133; neurotrophic factor; nerve growth factor 2; NGF-2; NGF2
• Gene ID: 4908
• mRNA Refseq: NM_001102654
• Protein Refseq: NP_001096124
• MIM: 162660
• Chromosome Location: 12p13
• Function: growth factor activity; nerve growth factor binding; neurotrophin receptor binding