Recombinant Human RNASE1, His-tagged
Cat.No. : | RNASE1-7682H |
Product Overview : | Recombinant Human Ribonuclease Pancreatic/RNASE1 is produced with our mammalian Cells expression system in HEK293. The target protein is expressed with sequence (Lys29Thr156) of Human RNASE1 fused with a 6His tag at the Cterminus. |
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Description : | Ribonuclease Pancreatic is a secreted enzyme that belongs to the pancreatic ribonuclease family. RNASE1 is an endonuclease that cleaves internal phosphodiester RNA bonds on the 3"side of pyrimidine bases. RNASE1 prefers poly(C) as a substrate and hydrolyzes 2",3"cyclic nucleotides, with a pH optimum near 8.0. RNASE1 acts on single stranded and double stranded RNA. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | His |
Form : | Supplied as a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, 10% Glycerol, pH 7.4 |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Notes : | For research use only. |
Storage : | Store at less than 20°C. stable for 6 months after receipt.Please minimize freezethaw cycles. |
Gene Name : | RNASE1 ribonuclease, RNase A family, 1 (pancreatic) [ Homo sapiens ] |
Official Symbol : | RNASE1 |
Synonyms : | RNASE1; ribonuclease, RNase A family, 1 (pancreatic); RNS1; ribonuclease pancreatic; RIB-1; RNase 1; RNase A; HP-RNase; RNase upI-1; ribonuclease 1; ribonuclease A; RIB1; MGC12408; |
Gene ID : | 6035 |
mRNA Refseq : | NM_002933 |
Protein Refseq : | NP_002924 |
MIM : | 180440 |
UniProt ID : | P07998 |
Chromosome Location : | 14q11.1 |
Function : | endonuclease activity; hydrolase activity; nucleic acid binding; pancreatic ribonuclease activity; protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewRNASE1 have strong anti-contamination ability and are not easily contaminated, which ensures the quality of the product.
This stability of RNASE1 is impressive, maintaining stable performance regardless of the environment, demonstrating excellent quality and reliability.
The catalytic activity of RNASE1 is excellent, which can simplify complex chemical reactions and improve yields, and has high scientific research value.
Q&As (6)
Ask a questionThere is a correlation between RNASE1 protein and insulin secretion. Studies have shown that RNASE1 protein can regulate insulin synthesis and secretion by affecting the internal environment of pancreatic islets.
At present, the regulatory mechanism of RNASE1 protein is poorly understood. However, studies have found that some factors such as glucagon and insulin may be involved in regulating the expression and activity of RNASE1 protein.
The RNASE1 protein is thought to have potential for anti-tumor effects. Studies have shown that it can induce apoptosis of tumor cells and inhibit the proliferation and invasion ability of tumor cells.
RNASE1 protein has certain application potential in clinical diagnosis. Its hydrolyzed RNA properties can be used to measure the content and stability of RNA, and then evaluate the condition and treatment effect of certain diseases.
The RNASE1 protein participates in the RNA degradation process in the digestive system by cutting the phosphodiester bond of the RNA molecule and degrading it into shorter RNA fragments.
The main expression and secretion site of RNASE1 protein is the pancreas, while the expression in the gut is relatively low. But in some cases, other nucleases in the gut may perform a similar function.
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