Recombinant Human S100 Calcium Binding Protein A9, Cys3Ser Mutated

• Cat.No.: S100A9-433H
• Product Overview: Recombinant Human S100 Calcium Binding Protein A9 cloned from human cDNA, was expressed inE.coli. The protein consists of the human S100A9 (residues 1-114) with a mutation at position 3: Cys3Ser. MW = 13.2 kDa.

Specification

• Cat. No.: S100A9-433H
• Description: Protein S100-A9 is a protein that in humans is encoded by the S100A9 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.
• Source: E.Coli.
• Purity: > 95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight of (<20 kDa).
• Supplied As: 0.5 mg at 1 mg/ml in Tris-HCl 10mM, NaCl 100mM pH 7.5 CaCl2 1mM. The concentration is calculated from the absorbance at 280nm (e280 = 6990M-1cm-1).
• Characteristics: Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum 1mM.
• Storage: -20º C. The protein is stable at 4 ºC for at least 3 days and at 25 ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20º C. Avoid repeated freeze/defrost cycles.
• Tag: Non
• Protein length: 1-114

Gene Information

• Gene Name: S100A9 S100 calcium binding protein A9 [ Homo sapiens ]
• Synonyms: S100A9; S100 calcium binding protein A9; MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG;MRP14; 60B8AG; MAC387; S100A9; S100; MRP-14 calcium-binding protein A9 (calgranulin B); S100 calcium binding protein A9 (calgranulin B); calgranulin B; OTTHUMP00000015331; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain
• Gene ID: 6280
• mRNA Refseq: NM_002965
• Protein Refseq: NP_002956
• MIM: 123886
• UniProt ID: P06702
• Chromosome Location: 1q21
• Function: calcium ion binding; protein binding; signal transducer activity

Reviews

08/17/2021

This includes complementary reagents, protocols, and access to an extensive knowledge base, all aimed at streamlining the trial process and maximizing the chances of achieving meaningful results.

06/20/2016

By choosing the S100A9 protein and partnering with the manufacturer, researchers can confidently conduct their trials, achieve reliable results, and contribute to groundbreaking discoveries.

04/04/2016

Collaborating with the manufacturer opens up possibilities for potential collaboration and exchange of information with a wider scientific community, allowing researchers to stay at the forefront of advancements in their respective fields.

Q&As

How is S100A9 protein measured in clinical settings?

S100A9 levels can be measured using various laboratory techniques, such as ELISA (enzyme-linked immunosorbent assay).

Are there any therapies or drugs targeting S100A9 in clinical development?

Some research is exploring the development of drugs that target S100A9 to modulate inflammation, but clinical applications are still in the experimental phase.

Can S100A9 levels be used as a biomarker for specific diseases?

Yes, elevated S100A9 levels have been associated with conditions like rheumatoid arthritis and inflammatory bowel disease, making it a potential biomarker.

Can S100A9 be used to predict disease outcomes?

Elevated S100A9 levels have been linked to poorer outcomes in certain diseases, making it a potential predictor of disease severity.

Are there any genetic factors that influence S100A9 levels?

Genetic variations can influence S100A9 expression, and these variations may impact an individual's susceptibility to certain diseases.