| Description : |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
89.7 kDa |
| AA Sequence : |
MAVWIQAQQLQGEALHQMQALYGQH FPIEVRHYLSQWIESQAWDSVDLDN PQENIKATQLLEGLVQELQKKAEHQ VGEDGFLLKIKLGHYATQLQNTYDR CPMELVRCIRHILYNEQRLVREANN GSSPAGSLADAMSQKHLQINQTFEE LRLVTQDTENELKKLQQTQEYFIIQ YQESLRIQAQFGPLAQLSPQERLSR ETALQQKQVSLEAWLQREAQTLQQY RVELAEKHQKTLQLLRKQQTIILDD ELIQWKRRQQLAGNGGPPEGSLDVL QSWCEKLAEIIWQNRQQIRRAEHLC QQLPIPGPVEEMLAEVNATITDIIS ALVTSTFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNDYSGEILNNC CVMEYHQATGTLSAHFRNMSLKRIK RSDRRGAESVTEEKFTILFESQFSV GGNELVFQVKTLSLPVVVIVHGSQD NNATATVLWDNAFAEPGRVPFAVPD KVLWPQLCEALNMKFKAEVQSNRGL TKENLVFLAQKLFNNSSSHLEDYSG LSVSWSQFNRENLPGRNYTFWQWFD GVMEVLKKHLKPHWNDGAILGFVNK QQAHDLLINKPDGTFLLRFSDSEIG GITIAWKFDSQERMFWNLMPFTTRD FSIRSLADRLGDLNYLIYVFPDRPK DEVYSKYYTPVPCESATAKAVDGYV KPQIKQVVPEFVNASADAGGGSATY MDQAPSPAVCPQAHYNMYPQNPDSV LDTDGDFDLEDTMDVARRVEELLGR PMDSQWIPHAQSTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
