| Description : |
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
128.1 kDa |
| AA Sequence : |
MNHQQQQQQQKAGEQQLSEPEDMEM EAGDTDDPPRITQNPVINGNVALSD GHNTAEEDMEDDTSWRSEATFQFTV ERFSRLSESVLSPPCFVRNLPWKIM VMPRFYPDRPHQKSVGFFLQCNAES DSTSWSCHAQAVLKIINYRDDEKSF SRRISHLFFHKENDWGFSNFMAWSE VTDPEKGFIDDDKVTFEVFVQADAP HGVAWDSKKHTGYVGLKNQGATCYM NSLLQTLFFTNQLRKAVYMMPTEGD DSSKSVPLALQRVFYELQHSDKPVG TKKLTKSFGWETLDSFMQHDVQELC RVLLDNVENKMKGTCVEGTIPKLFR GKMVSYIQCKEVDYRSDRREDYYDI QLSIKGKKNIFESFVDYVAVEQLDG DNKYDAGEHGLQEAEKGVKFLTLPP VLHLQLMRFMYDPQTDQNIKINDRF EFPEQLPLDEFLQKTDPKDPANYIL HAVLVHSGDNHGGHYVVYLNPKGDG KWCKFDDDVVSRCTKEEAIEHNYGG HDDDLSVRHCTNAYMLVYIRESKLS EVLQAVTDHDIPQQLVERLQEEKRI EAQKRKERQEAHLYMQVQIVAEDQF CGHQGNDMYDEEKVKYTVFKVLKNS SLAEFVQSLSQTMGFPQDQIRLWPM QARSNGTKRPAMLDNEADGNKTMIE LSDNENPWTIFLETVDPELAASGAT LPKFDKDHDVMLFLKMYDPKTRSLN YCGHIYTPISCKIRDLLPVMCDRAG FIQDTSLILYEEVKPNLTERIQDYD VSLDKALDELMDGDIIVFQKDDPEN DNSELPTAKEYFRDLYHRVDVIFCD KTIPNDPGFVVTLSNRMNYFQVAKT VAQRLNTDPMLLQFFKSQGYRDGPG NPLRHNYEGTLRDLLQFFKPRQPKK LYYQQLKMKITDFENRRSFKCIWLN SQFREEEITLYPDKHGCVRDLLEEC KKAVELGEKASGKLRLLEIVSYKII GVHQEDELLECLSPATSRTFRIEEI PLDQVDIDKENEMLVTVAHFHKEVF GTFGIPFLLRIHQGEHFREVMKRIQ SLLDIQEKEFEKFKFAIVMMGRHQY INEDEYEVNLKDFEPQPGNMSHPRP WLGLDHFNKAPKRSRYTYLEKAIKI HNTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
