Recombinant Mouse B2m Protein, MYC/DDK-tagged

• Cat.No.: B2m-685M
• Product Overview: Purified recombinant protein of full-length mouse beta-2 microglobulin (B2m), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 14.2 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: B2m beta-2 microglobulin [ Mus musculus (house mouse) ]
• Official Symbol: B2m
• Synonyms: B2m; beta-2 microglobulin; Ly-m11; beta2m; beta2-m; beta-2-microglobulin
• Gene ID: 12010
• mRNA Refseq: NM_009735
• Protein Refseq: NP_033865
• UniProt ID: P01887

Reviews

10/08/2022

To meet the needs of biological activity experiments

01/25/2022

High purity, no impurities.

09/10/2020

The expression level is high, which can meet the daily experimental needs.

Q&As

What is the normal reference range for B2M?

The normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.

Why is B2M reduced?

Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.

In which diseases does B2M play a role in the diagnosis and treatment?

B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.

What are the physiological functions of B2M?

It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.

What are the causes of elevated B2M?

The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.

How is B2M related to disease?

This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.