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Recombinant Mouse Bace1 Protein, Myc/DDK-tagged

Cat.No. : Bace1-1815M
Product Overview : Purified recombinant protein of mouse full-length beta-site APP cleaving enzyme 1 (Bace1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 55.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bace1 beta-site APP cleaving enzyme 1 [ Mus musculus (house mouse) ]
Official Symbol : Bace1
Synonyms : BACE1; beta-site APP cleaving enzyme 1; beta-secretase 1; ASP2; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; membrane-associated aspartic protease 2; beta-site amyloid precursor protein cleaving enzyme 1; C76936
Gene ID : 23821
mRNA Refseq : NM_011792
Protein Refseq : NP_035922
UniProt ID : P56818

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential side effects associated with BACE1 inhibition? 08/20/2021

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

How is BACE1 linked to Alzheimer's disease? 01/05/2020

BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.

How can BACE1 inhibitors potentially benefit Alzheimer's patients? 08/11/2018

BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.

Are there any ongoing clinical trials involving BACE1 inhibitors? 09/22/2017

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

Are there clinical applications of BACE1 inhibitors? 08/07/2016

Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.

Customer Reviews (3)

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Reviews
07/27/2020

    Such support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.

    12/23/2019

      A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.

      09/30/2019

        Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.

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