Recombinant Mouse C3 Protein, MYC/DDK-tagged

• Cat.No.: C3-732M
• Product Overview: Purified recombinant protein of full-length mouse complement component 3 (C3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
• Molecular Mass: 186.9 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: C3 complement component 3 [ Mus musculus (house mouse) ]
• Official Symbol: C3
• Synonyms: C3; complement component 3; ASP; Plp; HSE-MSF; AI255234; complement C3; acylation stimulating protein; complement component 3d; complement factor 3; EC 3.4.21.43
• Gene ID: 12266
• mRNA Refseq: NM_009778
• Protein Refseq: NP_033908
• UniProt ID: P01027