Recombinant Mouse CD28 Protein, Fc-tagged

• Cat.No.: CD28-625M
• Product Overview: Recombinant Mouse CD28 protein with Fc tag was expressed in HEK293.

Specification

• Description: Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).
• Source: HEK293
• Species: Mouse
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 41.7 kDa
• Protein length: 218
• AA Sequence: MTLRLLFLALNFFSVQVTENKILVK QSPLLVVDSNEVSLSCRYSYNLLAK EFRASLYKGVNSDVEVCVGNGNFTY QPQFRSNAEFNCDGDFDNETVTFRL WNLHVNHTDIYFCKIEFMYPPPYLD NERSNGTIIHIKEKHLCHTQSSPKL FWALVVVAGVLFCYGLLVTVALCVI WTNSRRNRLLQSDYMNMTPRRPGLT RKPYQPYAPARDFAAYRP
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: Cd28 CD28 antigen [ Mus musculus (house mouse) ]
• Official Symbol: CD28
• Synonyms: CD28; CD28 antigen; T-cell-specific surface glycoprotein CD28
• Gene ID: 12487
• mRNA Refseq: NM_007642
• Protein Refseq: NP_031668
• UniProt ID: P31041

Reviews

08/24/2021

Its unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.

08/24/2021

Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

08/06/2021

the CD28 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.

Q&As

Can CD28 protein be used for personalized medicine?

CD28 protein expression and function may be relevant for personalized treatment strategies in autoimmune diseases and cancer.

What are the potential clinical applications of targeting CD28 protein?

Targeting CD28 protein may have therapeutic potential in treating autoimmune diseases, cancer immunotherapy, and organ transplantation.

How does CD28 protein impact regulatory T cells (Tregs)?

CD28 signaling is important for the function and maintenance of regulatory T cells, which play a role in immune tolerance and suppression of autoimmunity.

How does CD28 protein impact cancer immunotherapy?

CD28 protein is involved in enhancing the anti-tumor immune response, making it a potential target for cancer immunotherapy.

Are there any approved therapies targeting CD28 protein?

Currently, there are no FDA-approved therapies specifically targeting CD28 protein, but research is ongoing in this area.