Recombinant Mouse FMS-like Tyrosine Kinase 3 Ligand
Cat.No. : | Flt3l-188M |
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Cat. No. : | Flt3l-188M |
Description : | Fms-related tyrosine kinase 3 ligand (FLT3LG) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, such as IL-7 and IL-3, Flt-3 ligand promotes long-term expansion and differentiation of human pro-B-cells.Flt3 ligand is a cytokine capable of inducing large numbers of dendritic cells that dramatically enhances the sensitivity of antigen-specific B and T cell responses to systemic injection of a soluble protein. Through a CD40-CD40 ligand-dependent mechanism Flt-3 Ligand influences the class of antibody produced and enables productive immune responses. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse Flt3-Ligand is Mr 18 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 18-32 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Publication : |
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination. (2015)
Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis (2013)
Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis (2012)
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Gene Name : | Flt3l FMS-like tyrosine kinase 3 ligand [ Mus musculus ] |
Synonyms : | Flt3l; FMS-like tyrosine kinase 3 ligand; Ly72L; Flt3lg; Flt3l |
Gene ID : | 14256 |
mRNA Refseq : | NM_013520 |
Protein Refseq : | NP_038548 |
UniProt ID : | P49772 |
Chromosome Location : | 7 B2-C; 7 23.0 cM |
Function : | cytokine activity; kinase activity; protein homodimerization activity; receptor tyrosine kinase binding; receptor tyrosine kinase binding |
Products Types
◆ Recombinant Protein | ||
Flt3l-285F | Active Recombinant Mouse Flt3l Protein, His-tagged | +Inquiry |
FLT3L-99M | Active Recombinant Mouse FLT3L Protein | +Inquiry |
Flt3l-26M | Active Recombinant Mouse Flt3l Protein (Gly27-Arg188), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Flt3l-3046M | Recombinant Mouse Flt3l Protein, Myc/DDK-tagged | +Inquiry |
Flt3l-064M | Active Recombinant Mouse Flt3l Protein | +Inquiry |
◆ Lysates | ||
FLT3LG-1387MCL | Recombinant Mouse FLT3LG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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