Recombinant Mouse Gfra1 Protein, Myc/DDK-tagged
Cat.No. : | Gfra1-3197M |
Product Overview : | Purified recombinant protein of mouse full-length glial cell line derived neurotrophic factor family receptor alpha 1 (Gfra1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 51.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Gfra1 |
Synonyms : | Gfra1; glial cell line derived neurotrophic factor family receptor alpha 1; GDNFR; AU042498; GDNF family receptor alpha-1; GDNFR-alpha-1; GFR alpha-1; TGF-beta-related neurotrophic factor receptor 1 |
Gene ID : | 14585 |
mRNA Refseq : | NM_010279 |
Protein Refseq : | NP_034409 |
UniProt ID : | P97785 |
Products Types
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GFRA1-80H | Recombinant Human GFRA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
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GFRA1-2040H | Recombinant Human GFRA1 Protein, Fc/His-tagged | +Inquiry |
◆ Lysates | ||
GFRA1-2692MCL | Recombinant Mouse GFRA1 cell lysate | +Inquiry |
GFRA1-2426HCL | Recombinant Human GFRA1 cell lysate | +Inquiry |
GFRA1-966CCL | Recombinant Canine GFRA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are exploring the modulation of GFRA1 for the treatment of neurodegenerative diseases.
GFRA1 is involved in neuroprotection by promoting the survival and maintenance of neurons, making it a potential target for therapeutic interventions.
GFRA1 is crucial for the development and function of the nervous system as it participates in the regulation of neuronal survival and differentiation.
Some therapeutic strategies aim to harness GFRA1 for promoting neuroregeneration, especially in the context of nerve injuries.
Research suggests that alterations in GFRA1 expression may serve as a potential biomarker for specific neurological disorders.
Customer Reviews (3)
Write a reviewWith their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the GFRA1 protein into my investigations.
The GFRA1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.
Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.
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