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Recombinant Mouse Gfra1 Protein, Myc/DDK-tagged

Cat.No. : Gfra1-3197M
Product Overview : Purified recombinant protein of mouse full-length glial cell line derived neurotrophic factor family receptor alpha 1 (Gfra1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 51.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 [ Mus musculus (house mouse) ]
Official Symbol : Gfra1
Synonyms : Gfra1; glial cell line derived neurotrophic factor family receptor alpha 1; GDNFR; AU042498; GDNF family receptor alpha-1; GDNFR-alpha-1; GFR alpha-1; TGF-beta-related neurotrophic factor receptor 1
Gene ID : 14585
mRNA Refseq : NM_010279
Protein Refseq : NP_034409
UniProt ID : P97785

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting GFRA1 for neurodegenerative diseases? 05/25/2021

Yes, several clinical trials are exploring the modulation of GFRA1 for the treatment of neurodegenerative diseases.

How does GFRA1 contribute to neuroprotection? 04/25/2020

GFRA1 is involved in neuroprotection by promoting the survival and maintenance of neurons, making it a potential target for therapeutic interventions.

How does GFRA1 influence the development and function of the nervous system? 10/10/2017

GFRA1 is crucial for the development and function of the nervous system as it participates in the regulation of neuronal survival and differentiation.

Are there any therapeutic strategies targeting GFRA1 for neuroregeneration? 10/26/2016

Some therapeutic strategies aim to harness GFRA1 for promoting neuroregeneration, especially in the context of nerve injuries.

Can GFRA1 protein be a biomarker for certain neurological disorders? 07/12/2016

Research suggests that alterations in GFRA1 expression may serve as a potential biomarker for specific neurological disorders.

Customer Reviews (3)

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Reviews
03/24/2022

    With their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the GFRA1 protein into my investigations.

    08/19/2020

      The GFRA1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

      03/11/2020

        Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.

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