Recombinant Mouse Il2rb protein, His-tagged

• Cat.No.: Il2rb-3101M
• Product Overview: Recombinant Mouse Il2rb protein(P16297)(24-240aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 29.3 kDa
• Protein length: 24-240aa
• AA Sequence: ASAAVKNCSHLECFYNSRANVSCMW SHEEALNVTTCHVHAKSNLRHWNKT CELTLVRQASWACNLILGSFPESQS LTSVDLLDINVVCWEEKGWRRVKTC DFHPFDNLRLVAPHSLQVLHIDTQR CNISWKVSQVSHYIEPYLEFEARRR LLGHSWEDASVLSLKQRQQWLFLEM LIPSTSYEVQVRVKAQRNNTGTWSP WSQPLTFRTRPADPMKE
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: Il2rb interleukin 2 receptor, beta chain [ Mus musculus ]
• Official Symbol: Il2rb
• Synonyms: IL2RB; interleukin 2 receptor, beta chain; interleukin-2 receptor subunit beta; IL-2RB; p70-75; IL-2R subunit beta; IL-2/15 receptor-beta; IL-2 receptor beta chain; IL-15 receptor beta chain; IL-2 receptor subunit beta; high affinity IL-2 receptor subunit beta; p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta; MGC118674
• Gene ID: 16185
• mRNA Refseq: NM_008368
• Protein Refseq: NP_032394

Reviews

09/07/2021

Immunogenicity is very weak and does not cause an immune response.

12/27/2019

Detection method is very sensitive and can detect trace amounts of protein.

08/15/2019

Preparation process is very simple and can be easily prepared.

Q&As

What is IL2RB and what are its clinical applications?

It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

What is the effect of IL2RB in the treatment of tumor?

There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

What is the therapeutic mechanism of IL2RB in clinical use?

This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

What diseases is IL2RB associated with?

IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

Can IL2RB be an alternative to traditional treatment?

IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

Does IL2RB have side effects?

IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.