Recombinant Mouse Inpp5d Protein, Myc/DDK-tagged
Cat.No. : | Inpp5d-3547M |
Product Overview : | Purified recombinant protein of mouse full-length inositol polyphosphate-5-phosphatase D (Inpp5d), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 133.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Inpp5d inositol polyphosphate-5-phosphatase D [ Mus musculus (house mouse) ] |
Official Symbol : | Inpp5d |
Synonyms : | INPP5D; inositol polyphosphate-5-phosphatase D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; SIP-145; p150Ship; SH2 containing inositol phosphotase; SH2-containing inositol phosphatase SHIP; SH2 domain-containing inositol phosphatase 1; inositol polyphosphate-5-phosphatase, 145 kDa; SH2 domain-containing inositol 5-phosphatase 1; SH2 domain-containing inositol-5-phosphatase 1; inositol polyphosphate-5-phosphatase of 145 kDa; Src homology 2 domain-containing inositol-5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SHIP; SHIP1; SHIP-1; s-SHIP; AI323613; MGC117680 |
Gene ID : | 16331 |
mRNA Refseq : | NM_010566 |
Protein Refseq : | NP_034696 |
UniProt ID : | Q9ES52 |
Products Types
◆ Recombinant Protein | ||
INPP5D-1185H | Recombinant Human INPP5D Protein, His (Fc)-Avi-tagged | +Inquiry |
INPP5D-2729R | Recombinant Rat INPP5D Protein, His (Fc)-Avi-tagged | +Inquiry |
INPP5D-359H | Recombinant Human INPP5D Protein, Flag-tagged | +Inquiry |
INPP5D-4557M | Recombinant Mouse INPP5D Protein, His (Fc)-Avi-tagged | +Inquiry |
INPP5D-3073R | Recombinant Rat INPP5D Protein | +Inquiry |
◆ Lysates | ||
INPP5D-5198HCL | Recombinant Human INPP5D 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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