Recombinant Mouse Mertk Protein, hFc tagged, Biotinylated

• Cat.No.: Mertk-04M
• Product Overview: Biotinylated Recombinant Mouse MerTK (C-hFc) is produced by Human Cells. The target gene encoding Glu23 - Phe498 is expressed with a C-hFc tag.

Specification

• Description: Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Source: Human Cells
• Species: Mouse
• Tag: hFc
• Protein Length: Glu23 - Phe498
• Endotoxin: Less than 0.1 ng/μg (1 EU/μg)
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4
• Shipping: Ambient

Gene Information

• Gene Name: Mertk c-mer proto-oncogene tyrosine kinase [ Mus musculus (house mouse) ]
• Official Symbol: Mertk
• Synonyms: MERTK; Mer
• Gene ID: 17289
• mRNA Refseq: NM_008587
• Protein Refseq: NP_032613
• UniProt ID: Q12866