Recombinant Full Length Mouse Prmt5 Protein, Myc/DDK-tagged

• Cat.No.: Prmt5-5133M
• Product Overview: Purified recombinant protein of mouse full-length protein arginine N-methyltransferase 5 (Prmt5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 72.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Prmt5 protein arginine N-methyltransferase 5 [ Mus musculus (house mouse) ]
• Official Symbol: Prmt5
• Synonyms: PRMT5; protein arginine N-methyltransferase 5; SKB1 homolog; Jak-binding protein 1; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5; Jbp1; Skb1
• Gene ID: 27374
• mRNA Refseq: NM_013768
• Protein Refseq: NP_038796
• UniProt ID: Q8CIG8

Reviews

02/18/2023

Great performance in ELISA.

11/01/2018

Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.

10/30/2016

The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

Q&As

Are there any ongoing clinical trials targeting PRMT5?

Yes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.

How does PRMT5 affect cellular differentiation?

PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.

Can PRMT5 inhibitors be used in combination therapies?

Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.

How does PRMT5 contribute to epigenetic regulation?

PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.

How does PRMT5 influence neurodegenerative diseases?

PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.