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Recombinant Mouse Pten Protein, Myc/DDK-tagged

Cat.No. : Pten-5216M
Product Overview : Purified recombinant protein of mouse full-length phosphatase and tensin homolog (Pten), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 47.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ]
Official Symbol : Pten
Synonyms : PTEN; phosphatase and tensin homolog; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mutated in multiple advanced cancers 1; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; MGC183880
Gene ID : 19211
mRNA Refseq : NM_008960
Protein Refseq : NP_032986
UniProt ID : O08586

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Apart from its lipid phosphatase activity, what additional function has been attributed to PTEN? 10/01/2022

In addition to its lipid phosphatase activity, PTEN has an additional function known as a scaffolding protein that contributes to its tumor-suppressive role.

In which cellular compartment does PTEN primarily exert its lipid phosphatase function? 01/02/2022

PTEN primarily exerts its lipid phosphatase function in the cytoplasm, where it regulates the PI3K/AKT pathway.

What is the significance of the FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis? 03/30/2020

The significance of FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis involves the loss of PTEN's tumor-suppressive functions, leading to uncontrolled cell growth.

How is the expression of nuclear PTEN (核PTEN) regulated, especially in the context of tumorigenesis? 08/22/2019

The expression of nuclear PTEN (核PTEN) is regulated, especially in the context of tumorigenesis, through mechanisms involving post-translational modifications and subcellular localization.

What differences are observed in the expression patterns of nuclear PTEN and cytoplasmic PTEN (浆PTEN) in various cancer processes? 07/25/2019

Differences in expression patterns of nuclear PTEN and cytoplasmic PTEN in various cancer processes include alterations in nuclear PTEN levels contributing to tumorigenesis.

What is the classical function of the PTEN protein encoded by the PTEN gene? 04/03/2019

The classical function of the PTEN protein is to regulate cell growth and prevent tumor formation by suppressing the PI3K/AKT signaling pathway.

What role does nuclear PTEN play in mediating the non-phosphatase-dependent function? 10/28/2018

Nuclear PTEN plays a role in mediating the non-phosphatase-dependent function related to genomic stability and DNA repair.

Customer Reviews (3)

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Reviews
11/05/2022

    Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

    01/18/2021

      The insights gained from the product's application justified its cost, marking a prudent investment in our research endeavors.

      12/20/2020

        Comprehensive documentation streamlined the integration of the product into our experimental workflow.

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