Recombinant Mouse Pten Protein, Myc/DDK-tagged
Cat.No. : | Pten-5216M |
Product Overview : | Purified recombinant protein of mouse full-length phosphatase and tensin homolog (Pten), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 47.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ] |
Official Symbol : | Pten |
Synonyms : | PTEN; phosphatase and tensin homolog; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mutated in multiple advanced cancers 1; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; MGC183880 |
Gene ID : | 19211 |
mRNA Refseq : | NM_008960 |
Protein Refseq : | NP_032986 |
UniProt ID : | O08586 |
Products Types
◆ Recombinant Protein | ||
PTEN-078H | Recombinant Human PTEN Protein, His-tagged | +Inquiry |
PTEN-1792H | Recombinant Human PTEN Protein, His (Fc)-Avi-tagged | +Inquiry |
PTEN-18H | Active Recombinant Human PTEN Protein (Thr2-Val403), C-6×His-tagged | +Inquiry |
Pten-1996M | Recombinant Mouse Pten Protein, His-tagged | +Inquiry |
PTEN-31H | Recombinant Human PTEN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PTEN-2721HCL | Recombinant Human PTEN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIn addition to its lipid phosphatase activity, PTEN has an additional function known as a scaffolding protein that contributes to its tumor-suppressive role.
PTEN primarily exerts its lipid phosphatase function in the cytoplasm, where it regulates the PI3K/AKT pathway.
The significance of FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis involves the loss of PTEN's tumor-suppressive functions, leading to uncontrolled cell growth.
The expression of nuclear PTEN (核PTEN) is regulated, especially in the context of tumorigenesis, through mechanisms involving post-translational modifications and subcellular localization.
Differences in expression patterns of nuclear PTEN and cytoplasmic PTEN in various cancer processes include alterations in nuclear PTEN levels contributing to tumorigenesis.
The classical function of the PTEN protein is to regulate cell growth and prevent tumor formation by suppressing the PI3K/AKT signaling pathway.
Nuclear PTEN plays a role in mediating the non-phosphatase-dependent function related to genomic stability and DNA repair.
Customer Reviews (3)
Write a reviewGel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.
The insights gained from the product's application justified its cost, marking a prudent investment in our research endeavors.
Comprehensive documentation streamlined the integration of the product into our experimental workflow.
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