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Recombinant Mouse Rcvrn Protein, His-tagged

Cat.No. : Rcvrn-001M
Product Overview : Recombinant Mouse recoverin(33-293aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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Description : Recoverin also known as Rcvrn, is a heterogeneously acylated calcium-binding and intracellular signal transduction protein in the photoreceptor cells of retina. Recoverin contains four EF-hands, of which two bind Ca. Ca-induced extrusion of the acyl group from a hydrophobic cleft in the protein drives the translocation of recoverin from solution to the disc membrane. Recently, recoverin is a detectable serologic protein that is expressed in patients with cancer-associated retinopathy, a paraneoplastic syndrome.
Source : E.coli
Species : Mouse
Tag : His
Form : Liquid
Molecular Mass : 25.8 kDa
AASequence : MGSSHHHHHHSSGLVPRGSHMGSMG NSKSGALSKEILEELQLNTKFTEEE LSAWYQSFLKECPSGRITRQEFESI YSKFFPDSDPKAYAQHVFRSFDANS DGTLDFKEYVIALHMTTAGKPTQKL EWAFSLYDVDGNGTISKNEVLEIVM AIFKMIKPEDVKLLPDDENTPEKRA EKIWAFFGKKEDDKLTEEEFIEGTL ANKEILRLIQFEPQKVKERIKEKKQ
Purity : > 90% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1.0 mg/mL (determined by Absorbance at 280nm)
Storage Buffer : In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. 1mM DTT.
Warning : For research use only. This product is not intended or approved for human, diagnostics or veterin
Gene Name : Rcvrn recoverin [ Mus musculus (house mouse) ]
Official Symbol : Rcvrn
Synonyms : CAR; S-modulin; recoverin; 23 kDa photoreceptor cell-specific protein; cancer-associated retinopathy protein; guanylate cyclase activator
Gene ID : 19674
mRNA Refseq : NM_009038
Protein Refseq : NP_033064
UniProt ID : P34057

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific populations that may benefit more from RCVRN-targeted therapies? 03/02/2022

Individuals with genetic mutations affecting RCVRN and those with early-stage retinal diseases may potentially benefit more from targeted therapies.

How does the expression of RCVRN change with age, and does this have implications for age-related vision disorders? 10/29/2021

The expression of RCVRN may change with age, and understanding these changes can provide insights into age-related vision disorders.

How is the level of RCVRN expression correlated with the progression of certain retinal disorders? 01/22/2021

Changes in RCVRN expression levels may correlate with the progression of retinal disorders, serving as a potential indicator of disease severity.

Are there ongoing clinical trials exploring the use of RCVRN-based therapies? 02/11/2017

Some clinical trials are investigating the safety and efficacy of gene therapies targeting the RCVRN gene for treating specific eye conditions.

How might the manipulation of RCVRN expression offer therapeutic benefits for patients with vision impairments? 03/04/2016

Modulating RCVRN expression could potentially restore or enhance photoreceptor function, providing therapeutic benefits for vision-impaired individuals.

Customer Reviews (3)

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Reviews
02/16/2020

    Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

    05/29/2018

      In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

      06/24/2016

        Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

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