Recombinant Mouse Spn Protein, His&GST-tagged

• Cat.No.: Spn-2094M
• Product Overview: Recombinant Mouse Spn Protein (Asp20-Gly248) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is integral component of plasma membrane. Orthologous to human SPN (sialophorin).
• Source: E. coli
• Species: Mouse
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 52.5 kDa
  Accurate Molecular Mass: 70 kDa
• Protein length: Asp20-Gly248
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Spn sialophorin [ Mus musculus (house mouse) ]
• Official Symbol: Spn
• Synonyms: SPN; sialophorin; leukosialin; 3E8 antigen; lymphocyte antigen 48; leukocyte sialoglycoprotein; B-cell differentiation antigen LP-3; Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
• Gene ID: 20737
• mRNA Refseq: NM_001037810
• Protein Refseq: NP_001032899
• UniProt ID: P15702

Reviews

06/23/2023

Accurate and timely results, crucial for research progress.

10/02/2018

Instrumental in our research achievements, highly trusted.

03/26/2018

Efficient and dependable, aids our research significantly.

Q&As

What is the primary role of SPN in immune cell function?

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders?

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response?

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration?

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system?

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases?

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling?

It contributes to immune cell signaling, influencing cell activation and response to stimuli.