Recombinant Rat Fgf23 protein, His-tagged
|Product Overview :||Recombinant Rat Fgf23(aa 25-251) fused with His tag was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||FGF23 is a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR).|
|Source :||E. coli|
|Form :||20 mM Tris, pH 8.0, 500 mM NaCl, 50% glycerol|
|Molecular Mass :||29.6 Kd|
|AA Sequence :||YSDTSPLLGS NWGSLTHLYT ATARNSYHLQ IHRDGHVDGTPHQTIYSALM ITSEDAGSVV IIGAMTRRFL CMDLRGNIFGSYHFSPENCR FRQWTLENGY DVYLSPKHHY LVSLGRSKRIFQPGTNPPPF SQFLARRNEV PLLHFYTARP RRHTRSAEDPPERDPLNVLK PRPRATPIPV SCSRELPSAE EGGPAASDPLGVLRRGRGDA RRGAGGTDRC RPFPRFV|
|Storage :||Long term: -80 centigrade; Short term: -20 centigrade. Avoid freeze-thaw cycles.|
|Gene Name :||Fgf23 fibroblast growth factor 23 [ Rattus norvegicus ]|
|Official Symbol :||Fgf23|
|Synonyms :||FGF23; fibroblast growth factor 23; FGF-23;|
|Gene ID :||170583|
|mRNA Refseq :||NM_130754|
|Protein Refseq :||NP_570110|
|UniProt ID :||Q8VI82|
|Chromosome Location :||4q42|
|Pathway :||Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c and Klotho ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem|
|Function :||fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; growth factor activity; type 1 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
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Excellent results, high purity. -
Reliable and effective product. -
Quick delivery, product works. -
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