|Official Full Name||angiopoietin 2|
|Background||The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ANGPT2 involved in several pathways and played different roles in them. We selected most pathways ANGPT2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ras signaling pathway||PAK2; RIN1; PTPN11; PLA2G2E; RRAS; RASAL1; FGF20; CSF1; FGF19; KSR1|
|Rap signaling pathway||LPAR2; FGF6; FGF11; PDGFRB; FGF5; PIK3CB; FGF10; RAPGEF1; GNAI1; CALML3|
|HIF- signaling pathway||HIF1A; VEGFA; ALDOA; HK3; SLC2A1; CAMK2A; HMOX1; ENO2; HKDC1; Trf|
|PIK-Akt signaling pathway||ITGA10; LPAR6; VTN; COL6A6; IL7R; GNG5; PRKCA; GNG7; PKN2; MAPK1|
ANGPT2 has several biochemical functions, for example, metal ion binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT2 itself. We selected most functions ANGPT2 had, and list some proteins which have the same functions with ANGPT2. You can find most of the proteins on our site.
|metal ion binding||HMOX2A; HMGCLL1; PRKCD; ZSWIM7; GM757; TRIM35-35; ARG2; ATP11A; RASA3; ZNF446|
|protein binding||DOCK4; PPP4R4; CASP10; RAG1; IFI6; ZFYVE21; GLTP; C9orf43; CLNS1A; UHMK1|
|receptor binding||TNFSF10; ACOX2; WNT7A; SLC39A1; SLC9A3R1; LYN; MSN; CLCF1; PDGFRB; GUSB|
|receptor tyrosine kinase binding||ANXA5; ARHGEF16; FIZ1; TOB1; CPNE3; NCK1; SOCS5; PTPN1; FLT3LG; PTPN2|
ANGPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT2.
daap-5; TEK; daap-4; VEGFA; ANXA7; CDKN1A; CSNK2B; IQCB1