FGFR1
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Official Full Name
fibroblast growth factor receptor 1
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Overview
Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. -
Synonyms
FLG; FGFR1; fibroblast growth factor receptor 1; CEK; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; H2; H3; H4; H5; Basic fibroblast growth factor receptor 1; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Heparin binding growth factor receptor;
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- N/A
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- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- FGFR1 Related Articles
- FGFR1 Related Gene Family
- FGFR1 Related Research Area
- FGFR1 Related Signal Pathway
FGFR1 involved in several pathways and played different roles in them. We selected most pathways FGFR1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | STMN1B;ARR3B;PRKACBA;CACNG8;PPP3CA;GRB2;MAPK9;NTRK2B;FGF10 |
Ras signaling pathway | RASAL2;Pdgfa&Pdgfb;FGF11;ANGPT4;HRAS;MAPK3;PRKCB;PLA2G12A;KLK1B4 |
Rap signaling pathway | Fgf15;MAPK12;ACTG1;LPAR2;MAP2K3;RAPGEF6;FGF12;Adcy4;FGF17 |
PIK-Akt signaling pathway | PPP2R1B;GNG5;FN1;NGF;RPS6KB1;MLST8;FGF8;LAMA4;TCL1B |
Adherens junction | TCF7;CSNK2A1;FGFR1A;RHOAA;ACTN3B;TGFBR1B;SMAD4;WASL;FYNB |
Signaling pathways regulating pluripotency of stem cells | ESRRB;ID2;NODAL;TBX3;DLX5;ISL1;STAT3;SOX2;SMAD9 |
Regulation of actin cytoskeleton | ITGB8;ITGB7;EZR;FGF18A;FGF12A;GNG12;SLC9A1;NCKAP1L;PFN1 |
Pathways in cancer | BIRC8;GNG11;RXRG;SPI1;NCOA4;RAD51;WNT2B;MSH6;BCL2 |
Proteoglycans in cancer | MAP2K2;PIK3CB;ESR1;PIK3CD;ROCK2;SMAD2;ROCK1;ITGAV;PTPN11 |
Prostate cancer | CASP9;RB1;AKT1;FOXA1;INSRR;PDGFA;CREB3L1;SPINK1;BAD |
Melanoma | FGF16;FGF8;IGF1R;HRAS;MITF;KRAS;FGF7;FGF19;FGFR1 |
Central carbon metabolism in cancer | PDGFRA;SIRT6;MAPK3;MAP2K2;HIF1A;SLC16A3;PDHA2;PIK3CD;SCO2 |
FGFR1 has several biochemical functions, for example, ATP binding, cell adhesion molecule binding, fibroblast growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1 itself. We selected most functions FGFR1 had, and list some proteins which have the same functions with FGFR1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | P2RX4A;PEO1;DSTYK;CHORDC1;LMTK2;ATP13A3;KCNJ10;DDX39AA;PANK2 |
cell adhesion molecule binding | ITGB7;PVRL4;VCAM1;CXADR;NLGN4Y;SDCBP;PVRL3B;CD226;AMICA1 |
fibroblast growth factor binding | S100A13;FIBPA;SCN5A;CXCL13;FGFR3;FGFRL1;CEP57;FGFR2;RPS19 |
fibroblast growth factor-activated receptor activity | FGFR4;FGFR1A;FGFR1;FGFR1B;FGFR3;FGFR2;FGFRL1 |
glycoprotein binding | CDH1;CSNK1D;F7;BMPR1B;FLNA;RAB14;LDLR;FYN;FBXO17 |
heparin binding | CECR1;FSTL1;VEGFAA;LPA;ADAMTS1;FGFBP3;CXCL11;MSTN;CYR61L1 |
identical protein binding | HAPLN2;BCL2;DRG1;VCP;G6PDX;DIAPH1;TPRGL;BNIP2;MID1 |
protein binding | TRPM8;THBS2;CARS;PIF1;CLDN1;TTC35;C19orf60;CDC20;RPN1 |
protein complex binding | PPFIA2;RAP1A;LCK;PDZK1;LCA5;PEX1;ULK1;ABI1;MTHFR |
protein homodimerization activity | KIAA0947;GIMAP7;VEGFA;APOA2;WWTR1;ACTN2;AMICA1;GZMA;TIRAP |
protein tyrosine kinase activity | HCK;KITA;ERBB4;FYNB;MAP3K9;DYRK1A;BCR;FGR;PDGFRB |
FGFR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1.
PLCG1; HTR1A; FGF2
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Q&As (5)
Ask a questionDEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.
Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.
While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.
DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.
DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.
Customer Reviews (3)
Write a reviewFGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.
When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.
The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.
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