fgfr1
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  • Official Full Name
  • fibroblast growth factor receptor 1
  • Background
  • Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome.
  • Synonyms
  • FLG; FGFR1; fibroblast growth factor receptor 1; CEK; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; H2; H3; H4; H5; Basic fibroblast growth factor receptor 1; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Heparin binding growth factor receptor
Cat.#:FGFR1-384HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, Strep-tagged
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Cat.#:FGFR1-715HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-1133HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-2054HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, MYC/DDK-tagged
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Cat.#:FGFR1-2056HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-4121HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR1 Protein, GST/His-tagged
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Cat.#:FGFR1-4122HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR1 Protein
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Cat.#:FGFR1-4123HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR1 Protein, GST-tagged
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Cat.#:FGFR1-5417HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, His-tagged
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Cat.#:FGFR1-316HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, His-tagged
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Cat.#:FGFR1-01HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged
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Cat.#:FGFR1-111HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR1 protein, T7/His-tagged
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Cat.#:FGFR1-138HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, Fc-His tagged
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Cat.#:FGFR1-18HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, His-tagged
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Cat.#:FGFR1-207HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-208HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 protein, DDK/His-tagged
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Cat.#:FGFR1-210HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 protein, DDK/His-tagged
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Cat.#:FGFR1-211HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 protein, His-tagged
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Cat.#:FGFR1-236HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His & GST-tagged
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Cat.#:FGFR1-28834THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-28886THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-28890THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-312HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1, GST-tagged, Active
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Cat.#:FGFR1-45HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR1 protein, Flag-tagged, Biotinylated
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Cat.#:FGFR1-4843HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, GST-tagged
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Cat.#:FGFR1-485HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1(IIIb)
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Cat.#:FGFR1-486HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1(IIIc)
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Cat.#:FGFR1-487HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1 Beta
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Cat.#:FGFR1-498HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, Fc Chimera
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Cat.#:FGFR1-605HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR1, His-tagged, Biotinylated
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Cat.#:FGFR1-606HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR1, Fc-tagged, Biotinylated
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Cat.#:FGFR1-697HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, Fc Chimera
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Cat.#:FGFR1-8305HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:Fgfr1-4015MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr1, Fc tagged
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Cat.#:Fgfr1-4016MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr1, His tagged
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Cat.#:Fgfr1-1800RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgfr1 protein, His & S-tagged
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Cat.#:FGFR1-2338RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgfr1 protein, His/T7-tagged
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Cat.#:Fgfr1-2339RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fgfr1 protein, His-tagged
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Cat.#:FGFR1-55CTag:Fc
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1, Fc tagged
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Cat.#:FGFR1-67CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1 protein, His-tagged
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Cat.#:FGFR1-1704RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FGFR1 Protein, His-tagged
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Cat.#:FGFR1-66CTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR1 protein, His-tagged
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Cat.#:FGFR1-8817CTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR1 protein, Fc-tagged
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Cat.#:FGFR1-7059CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR1
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Cat.#:FGFR1-1405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 (Active), GST-tagged
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Cat.#:FGFR1-2765HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 cell lysate
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Cat.#:FGFR1-476HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1 cell lysate
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Cat.#:FGFR1-2133MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR1 cell lysate
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Cat.#:FGFR1-1171CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1 cell lysate
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Cat.#:Kit-1557Tag:
Source (Host):Species:
Product nameU2OS FGFR1 Bioassay Kit
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Cat.#:Kit-1590Tag:
Source (Host):Species:
Product nameFGFR1 Functional Assay Kit
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Involved Pathway

FGFR1 involved in several pathways and played different roles in them. We selected most pathways FGFR1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K3; FGF10A; PPP3R2; PDGFA; FGFR1; RPS6KAL; TGFB1; RPS6KA1; CACNG1; RAF1B
Ras signaling pathway
FGF5; IGF1R; PLA1A; KRAS; Fgf15; MAPK10; ETS1; FGFR3; GNG8; PRKCG
Rap signaling pathway
FGF22; MAGI2; MAP2K6; SKAP1; RAPGEF6; PRKCG; LPAR5; CALM3; IGF1R; ITGB2
PIK-Akt signaling pathway
ITGB6; PIK3R5; GNG13; LAMB1; ITGA4; Reln; CRTC2; PRKAA1; PDGFB; ANGPT2
Adherens junction
CSNK2A2A; WAS; ACTN1; WASF3; RAC3; NLK; FYNB; WASF2; SRC; PTPRJA
Signaling pathways regulating pluripotency of stem cells
JARID2; ACVR1C; OTX1; WNT9B; SETDB1; FGF2; ZIC3; ESX1; SMAD2; SMARCAD1
Regulation of actin cytoskeleton
ITGB8; PFN2L; ITGB3; PAK6B; GNA13A; ITGAE; BAIAP2A; GNA12A; MYLK3; ABI2B
Pathways in cancer
BIRC8; GSTP1; SMAD3; FZD7; WNT2; LAMA4; WNT2B; WNT6; RASSF5; FIGF
Proteoglycans in cancer
PDCD4; GRB2; PPP1R12C; Casp3; ITGB5; MAPK12; HPSE; HSPG2; CBLB; DROSHA
Prostate cancer
PIK3R1; FOXA1; INS1; TP53; MAP2K2; PDGFRB; NRAS; MAP4K1; IKBKB; FGFR1
Melanoma
FGF7; FGF4; FGF1; FGFR1; FGF19; FGF18; PIK3CA; MDM2; FGF13; PIK3R1
Central carbon metabolism in cancer
KIT; TRP53; PIK3CG; NRAS; FLT3; GLS2; SLC2A2; PIK3CA; IDH1; AKT1

Protein Function

FGFR1 has several biochemical functions, for example, ATP binding, cell adhesion molecule binding, fibroblast growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1 itself. We selected most functions FGFR1 had, and list some proteins which have the same functions with FGFR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ADCY1; MKNK2B; RPS6KA3A; GSS; ABCB6; C9orf96; STK11; PANK2; GNE; CLCN4
Function cell adhesion molecule binding
Related Protein CD1d1; NLGN1; DSG2; MSN; ITGA4; FGFR1; SMAGP; LILRB2; AMICA1; NRXN3
Function fibroblast growth factor binding
Related Protein FGFR4; FGFR1A; S100A13; RPS19; FIBPB; Api5; FIBP; FGFR1; HSPA9; FGFBP3
Function fibroblast growth factor-activated receptor activity
Related Protein FGFRL1; FGFR1B; FGFR3; FGFR2; FGFR4; FGFR1; FGFR1A
Function glycoprotein binding
Related Protein HFE2; PIP; VIM; SERPINA1E; CALR; SDC1; SELP; TGFB1; HSPA5; ITGB2
Function heparin binding
Related Protein FSTL1; RSPO3; UBE4A; CXCL13; SLIT1B; APLP1; SERPINE2; SELP; LRPAP1; PRELP
Function identical protein binding
Related Protein ALCAMB; SEPT7; HCN4; RIPK3; NONO; MRFAP1L1; COL7A1; AGER; ACTB; LTBR
Function protein binding
Related Protein NXF2; NADSYN1; LANCL1; HNRNPH1; TMED2; SYNM; CD40; VEGFAA; PIF1; LGALS8
Function protein complex binding
Related Protein FBN1; CASP8; PCSK2; VHLL; WASF1; FGFR1; CD2AP; MTAP1B; PEX1; RPH3A
Function protein homodimerization activity
Related Protein USF1; HMGCR; AOC3; NOD1; MUC13; TERF1; ADRA2C; S100A1; S100A6; SETMAR
Function protein tyrosine kinase activity
Related Protein Aatk; NEK1; FYN; PTK2AB; KIT; DYRK2; JAK2; ERBB2; TNK1; FGFR1A

Interacting Protein

FGFR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1.
PLCG1; HTR1A; FGF2

FGFR1 Related Articles

Stachowiak, MK; Birkaya, B; et al. "Nuclear FGF Receptor-1 and CREB Binding Protein: An Integrative Signaling Module". JOURNAL OF CELLULAR PHYSIOLOGY 230:989-1002(2015).
Ambrosini, S; Sarchielli, E; et al. FIBROBLAST GROWTH FACTOR AND ENDOTHELIN-1 RECEPTORS MEDIATE THE RESPONSE OF HUMAN STRIATAL PRECURSOR CELLS TO HYPOXIA. NEUROSCIENCE 289:123-133(2015).

FGFR1 Related Gene Family

Cytokines