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IL2RB

  • Official Full Name

    IL2RB interleukin 2 receptor, beta

  • Overview

    CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
  • Synonyms

    IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • 6His
  • Avi
  • Fc
  • hFc
  • His
  • hIgG1
  • hIgG4
  • His (Fc)
  • Twin
  • Strep
  • His\Avi
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL2RB-624H Active Recombinant Human IL2RB Sf21 Insect Cell N/A
Human IL2RB-783H Active Recombinant Human IL2RB protein(Met1-Asp239) HEK293 N/A Met1-Asp239
Human IL2RB-051H Active Recombinant Human IL2RB protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Ala27-Asp239
Human IL2RB-782H Recombinant Human IL2RB protein, Fc-tagged HEK293 human/IgG1/Fc Ala27-Asp239
Human IL2RB-785H Active Recombinant Human IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep Ala27-Asp239(IL-2RB)&Glu22-Ser212(IL-2RA)&Leu23-Asn254(IL-2RG)
Human IL2RB-1643H Recombinant Human Interleukin 2 Receptor, Beta Sf21 Insect Cell N/A
Human IL2RB-29776TH Recombinant Human IL2RB, Fc-tagged Fc
Human IL2RB-701H Active Recombinant Human IL2RB, HIgG1 Fc-tagged CHO Fc
Human IL2RB-700H Active Recombinant Human IL2RB, MIgG2a Fc-tagged CHO Fc
Human IL2RB-2906HCL Recombinant Human IL2RB cell lysate Human Cell N/A
Human IL2RB-066H Recombinant Human IL2RB Protein, C-His-tagged E.coli C-His
Human IL2RB-2310H Recombinant Human IL2RB Protein, His-tagged E.coli N-His Ala27-Thr240
Human IL2RB-420H Active Recombinant Human IL2RB Protein (Met1-Asp239), His-tagged Insect Cell His Met1-Asp239
Human IL2RB-5196H Recombinant Human IL2RB Protein HEK293 N/A
Human IL2RB-321H Recombinant Human IL2RB Protein, His-tagged HEK293 His 551
Human IL2RB-29H Recombinant Human IL2RB Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Ala27-Asp239
Human IL2RB-869HB Recombinant Human IL2RB protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala 27-Asp 239
Human IL2RB-5757HF Recombinant Full Length Human IL2RB Protein In Vitro Cell Free System 963 amino acids
Human IL2RB-1979H Active Recombinant Human IL2RB protein, mFc-tagged HEK293 mFc Met1-Asp239
Human IL2RB-0284H Active Recombinant Human IL2RB protein, Fc-tagged HEK293 Fc Ala27-Asp239
Human IL2RB-869H Recombinant Human IL2RB protein, His-Avi-tagged HEK293 His-Avi Ala 27-Asp 239
Human IL2RB-7125H Active Recombinant Human IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep Ala 27 - Asp 239 (IL-2RB) & Leu 23 - Asn 254 (IL-2RG)
Human IL2RB-5195H Recombinant Human IL2RB Protein Wheat Germ N/A
Human IL2RB-247H Recombinant Human IL2RB Protein (Ala27-Asp239), C-6×His-tagged HEK293 C-6×His Ala27-Asp239
Human IL2RB-201H Recombinant Human IL2RB Protein, His\Avi-tagged Human Cell His\Avi
Human IL2RB-4274H Recombinant Human IL2RB Protein (Met1-Asp239), C-His tagged Mammalian cells C-His Met1-Asp239
Human IL2RB-947H Active Recombinant Human IL2RB protein, His-tagged HEK293 His Ala 27 - Asp 239
Human IL2RB-4273H Recombinant Human IL2RB Protein (Met1-Asp239), C-Fc tagged Mammalian cells C-Fc Met1-Asp239
Mouse IL2RB-1257M Recombinant Mouse IL2RB Protein, His-tagged Yeast His
Mouse Il2rb-271R Recombinant Mouse Il2rb Protein, His-tagged E.coli His Ala27~Glu240
Mouse Il2rb-483M Recombinant Mouse Il2rb, His-tagged Human Cell His Met1-Glu240
Mouse IL2RB-744MCL Recombinant Mouse IL2RB cell lysate Human Cell N/A
Mouse Il2rb-3101M Recombinant Mouse Il2rb protein, His-tagged E.coli His 24-240aa
Mouse Il2rb-484M Recombinant Mouse Il2rb(Ala27-Glu240) Protein, C-Fc-tagged HEK293 Fc
Mouse IL2RB-0283M Active Recombinant Mouse IL2RB protein, His-tagged HEK293 His Ala27-Glu240
Rat IL2RB-3044R Recombinant Rat IL2RB Protein Mammalian Cell His
Rat Il2rb-22R Recombinant Rat Il2rb protein, His-tagged E.coli His
Rat IL2RB-951R Active Recombinant Rat IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep Ala27-Glu239(IL-2RB)&Glu22-Gln235(IL-2RA)&Ser25-Ala262(IL-2RG)
Rat IL2RB-2699R-B Recombinant Rat IL2RB Protein Pre-coupled Magnetic Beads HEK293
Rat IL2RB-2699R Recombinant Rat IL2RB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL2RB-9511R Active Recombinant Rat IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep Ala 27 - Glu 239 (IL-2RB) & Ser 25 - Ala 262 (IL-2RG)
Rhesus monkey IL2RB-1554R Recombinant Rhesus Monkey IL2RB Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey IL2RB-1555R Recombinant Rhesus Monkey IL2RB Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey IL2RB-1553R Recombinant Rhesus Monkey IL2RB Protein HEK293 N/A
Canine IL2RB-176C Recombinant Canine IL2RB, Fc-tagged Human Cell Fc Met1-Pro244
Canine IL2RB-741CCL Recombinant Canine IL2RB cell lysate Human Cell N/A
Canine IL2RB-0282C Recombinant Canine IL2RB protein, His-tagged HEK293 His Asn30-Pro246
Canine IL2RB-453C Recombinant Canine IL2RB Protein, His-tagged HEK293 His Met1-Pro244
Cynomolgus IL2RB-619C Recombinant Cynomolgus IL2RB Protein, His-tagged HEK293 His
Cynomolgus IL2RB-0281C Active Recombinant Cynomolgus IL2RB protein, His-tagged HEK293 His Ala27-Thr240
Homo sapiens (Human) RFL8063HF Recombinant Full Length Human Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-551)
Rattus norvegicus (Rat) RFL6695RF Recombinant Full Length Rat Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-537)
Rhesus IL2RB-619R Active Recombinant Rhesus IL2RB Protein, His-tagged HEK293 His Met1-Asp239
Rhesus IL2RB-454R Active Recombinant Rhesus IL2RB protein(Met1-Asp239), hFc-tagged HEK293 C-hFc Met1-Asp239
Rhesus IL2RB-1007R Active Recombinant Rhesus IL2RB Protein (Met1-Asp239), His-tagged HEK293 His Met1-Asp239
Rhesus Macaque IL2RB-2248R Recombinant Rhesus monkey IL2RB Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL2RB-2069R-B Recombinant Rhesus Macaque IL2RB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL2RB-2069R Recombinant Rhesus Macaque IL2RB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IL2RB-6828Z Recombinant Zebrafish IL2RB Mammalian Cell His
Pig IL2Rb-3328P Recombinant Pig IL2Rb protein, His-tagged E.coli His His243-Gln416
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL2RB Related Articles
  • IL2RB Related Gene Family
  • IL2RB Related Research Area
  • IL2RB Related Signal Pathway

IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFRSF10A;CCL20B;CCL3;GM1987;IFNGR2;HGF;CCL2;INHBE;TNFSF9
EndocytosisARFGAP2;SH3GL1;RAB4A;VPS28;AMPH;PDGFRA;MVB12BB;FOLR2;ADRB2A
PIK-Akt signaling pathwayTLR2;GNB3;GNG11;ITGA2;IFNA2;COL6A5;RAF1;LAMA2;ITGB3
Jak-STAT signaling pathwayIL24;IFNB;SOCS1A;IL6R;IL21;IL23;IFNA1;GH2;Il23a; Il12b
MeaslesIfna15;PRKCQ;RAB9A;TNFAIP3;IFNG;cgr2b;IL1B;CD209;IFNA12
HTLV-I infectionWNT5B;FZD5;IL2RB;WNT10B;TP53INP1;CCNB2;CRTC3;WNT16;PPP3CC
Transcriptional misregulation in cancerHOXA9;MEF2C;JMJD1C;FCGR1A;NGFR;HOXA10;MEIS1;RUNX2;ITGAM

IL2RB has several biochemical functions, for example, interleukin-2 binding, interleukin-2 receptor activity, contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.

Function Related Protein
interleukin-2 bindingIL2RA;IL2RG;IL2RB
interleukin-2 receptor activityIL2RB;IL2RA
contributes_to interleukin-2 receptor activityIL2RG;IL2RB
protein bindingTALDO1;RANBP6;JAK2;G0S2;TMEM31;PAK4;LRRC47;C5orf13;ZZZ3

IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.

IL15; IL15RA; ubiA; STAT5A; STAT5B; SHB

Ovsyannikova, IG; Haralambieva, IH; et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. GENE 510:59-65(2012).
Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
IL
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is IL2RB and what are its clinical applications? 09/18/2022

It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

What is the effect of IL2RB in the treatment of tumor? 05/27/2022

There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

What is the therapeutic mechanism of IL2RB in clinical use? 12/13/2021

This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

What diseases is IL2RB associated with? 06/07/2021

IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

Can IL2RB be an alternative to traditional treatment? 04/10/2020

IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

Does IL2RB have side effects? 06/22/2019

IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.

Customer Reviews (3)

Write a review
Reviews
09/07/2021

    Immunogenicity is very weak and does not cause an immune response.

    12/27/2019

      Detection method is very sensitive and can detect trace amounts of protein.

      08/15/2019

        Preparation process is very simple and can be easily prepared.

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