il2rb
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  • Official Full Name
  • IL2RB interleukin 2 receptor, beta
  • Background
  • CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
  • Synonyms
  • IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75;
Cat.#:IL2RB-1007RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus IL2RB Protein (Met1-Asp239), His-tagged
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Cat.#:IL2RB-420HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL2RB Protein (Met1-Asp239), His-tagged
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Cat.#:IL2RB-453CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine IL2RB Protein, His-tagged
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Cat.#:IL2RB-454RTag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus IL2RB Protein, Fc-tagged
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Cat.#:IL2RB-951RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL2RB Protein (Met1-Glu239), His-tagged
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Cat.#:IL2RB-5195HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL2RB Protein
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Cat.#:IL2RB-5196HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RB Protein
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Cat.#:IL2RB-1257MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL2RB Protein, His-tagged
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Cat.#:IL2RB-619CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus IL2RB Protein, His-tagged
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Cat.#:IL2RB-29776THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human IL2RB, Fc-tagged
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Cat.#:IL2RB-624HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IL2RB
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Cat.#:IL2RB-700HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2RB, MIgG2a Fc-tagged
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Cat.#:IL2RB-701HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2RB, HIgG1 Fc-tagged
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Cat.#:IL2RB-782HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RB, Fc tagged
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Cat.#:IL2RB-783HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RB, None tagged
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Cat.#:IL2RB-785HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RB Protein, His-tagged
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Cat.#:Il2rb-271RTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2rb Protein, His-tagged
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Cat.#:Il2rb-483MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il2rb, His-tagged
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Cat.#:Il2rb-22RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2rb protein, His-tagged
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Cat.#:IL2RB-3044RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL2RB Protein
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Cat.#:IL2RB-1553RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL2RB Protein
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Cat.#:IL2RB-1554RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL2RB Protein, hIgG1-tagged
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Cat.#:IL2RB-1555RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL2RB Protein, hIgG4-tagged
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Cat.#:IL2RB-2248RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL2RB Protein, His-tagged
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Cat.#:IL2RB-176CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine IL2RB, Fc-tagged
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Cat.#:IL2RB-6828ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL2RB
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Cat.#:IL2RB-1643HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Interleukin 2 Receptor, Beta
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Cat.#:IL2RB-2906HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RB cell lysate
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Cat.#:IL2RB-744MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL2RB cell lysate
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Cat.#:IL2RB-741CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine IL2RB cell lysate
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Involved Pathway

IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNL3; CCL26; TNFRSF10D; TNFRSF17; FLT3; IL6ST; TNFRSF21; IL12RB1; CCL5; CCL11
Endocytosis
PRKCI; ASAP1A; IGF1R; SMAP2; SNX32; PLD2; WIPF2; GRK1; WAS; SNX1
PIK-Akt signaling pathway
MAPK3; PPP2R5B; Il6ra; GNG11; IFNA12; KIT; IFNA10; PDGFRB; GRB2; PCK1
Jak-STAT signaling pathway
HRASA; PIK3R3B; IFNB1; PIM1; IL22RA2; SOCS7; STAT4; RAF1A; IL6ST; IL4
Measles
NFKBIB; BBC3; DOK1; PRKCQ; IFNA2; TNFSF10; IRF7; HSPA8; EIF2AK4; CCND2
HTLV-I infection
Pdgfa&Pdgfb; BCL2L1; HLA-DOB; TGFBR2; FZD7; HLA-DRB4; IKBKG; TGFB3; LTBR; GM-CSF
Transcriptional misregulation in cancer
PML; TGFBR2; NGFR; HIST1H3E; MMP3; FUS; SSX2; BCL2A1A; RUNX1T1; TCF3

Protein Function

IL2RB has several biochemical functions, for example, interleukin-2 binding, interleukin-2 receptor activity, contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-2 binding
Related Protein IL2RA; IL2RB; IL2RG
Function interleukin-2 receptor activity
Related Protein IL2RA; IL2RB
Function contributes_to interleukin-2 receptor activity
Related Protein IL2RB; IL2RG
Function protein binding
Related Protein PRKAG1; TBX5A; PEX16; F2RL1; KCNA5; CIZ1; DCAF12L1; TFIP11; HESX1; RASSF1

Interacting Protein

IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.
IL15; IL15RA; ubiA; STAT5A; STAT5B; SHB

IL2RB Related Articles

Ovsyannikova, IG; Haralambieva, IH; et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. GENE 510:59-65(2012).
Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).

IL2RB Related Gene Family

IL