nanog
Share
  • Official Full Name
  • Nanog homeobox
  • Background
  • NANOG (Homeobox protein NANOG) is a member of the Nanog homeobox family of DNA-binding proteins. It is expressed in embryonic stem cells and confers pluripotency on these cells. Once embryonic stem cells become differentiated, NANOG expression is suppressed. NANOG is involved in the Hedgehog/Gli1 signaling pathway which has been implicated in the development and growth of various types of tumors.
  • Synonyms
  • NANOG; Nanog homeobox; homeobox protein NANOG; ES cell-associated protein 4; homeobox transcription factor Nanog; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; ENK; ecat4; 2410002E02Rik
Cat.#:NANOG-3603HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NANOG, His-tagged
+Inquiry
Cat.#:NANOG-3604HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nanog
+Inquiry
Cat.#:NANOG-130HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NANOG protein, Arginine-tagged
+Inquiry
Cat.#:NANOG-159HTag:13-residue TAT
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NANOG Protein, 13-residue TAT-tagged
+Inquiry
Cat.#:NANOG-3605HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NANOG Protein, His/GST-tagged
+Inquiry
Cat.#:NANOG-8468HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NANOG, His-tagged
+Inquiry
Cat.#:NANOG-864HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NANOG
+Inquiry
Cat.#:Nanog-151MTag:TAT
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nanog, TAT-tagged
+Inquiry
Cat.#:NANOG-725CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NANOG Protein, His-tagged
+Inquiry
Cat.#:NANOG-3937CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NANOG
+Inquiry
Cat.#:NANOG-5682ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NANOG
+Inquiry
Cat.#:NANOG-3981HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NANOG 293 Cell Lysate
+Inquiry
Cat.#:Kit-2296Tag:
Source (Host):Species:
Product nameNanog (Human) Transcription Factor Activity Assay Kit
+Inquiry

Involved Pathway

NANOG involved in several pathways and played different roles in them. We selected most pathways NANOG participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NANOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
FGFR1; PIK3R5; HOXB1; REST; PIK3R1; WNT9A; ACVR2A; INHBE; RAF1; SKIL
Proteoglycans in cancer
CAV2; TGFB1; PIK3R5; ANK1; WNT7B; WNT2; PPP1CC; ACTG1; HPSE; MSN

Protein Function

NANOG has several biochemical functions, for example, DNA binding, sequence-specific DNA binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NANOG itself. We selected most functions NANOG had, and list some proteins which have the same functions with NANOG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HOXD3A; ZFP319; RNF11; BRPF1; TAF6L; FOXD1; THAP5; C17orf49; HMG20B; HES7
Function sequence-specific DNA binding
Related Protein ZBTB4; NEUROG2; FOXD5; PRDM5; VENTX; CUX2; LHX1; NKX2-4; LHX3; FOXG1A
Function transcription corepressor activity
Related Protein FOXP3; MYBBP1A; E2F6; ALX1; CBFA2T2; SMYD1; YY1; BASP1; AES; BCOR
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOMEZB; CARF; ZNF317; ATF4; MNX1; KAT7B; UBN2; ZNF133; SIX2; ZFP131

NANOG Related Articles

Khosravi-Farsani, S; Amidi, F; et al. Isolation and Enrichment of Mouse Female Germ Line Stem Cells. CELL JOURNAL 16:406-415(2015).
Tyagi, D; Perez, JB; et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. ANALYTICAL BIOCHEMISTRY 471:29-37(2015).