PCSK9 Protein, proprotein convertase subtilisin/kexin type 9

PCSK9

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PCSK9

Official Full Name proprotein convertase subtilisin/kexin type 9
Background This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Synonyms PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein;
    • Species :
    • Cynomolgus
    • Hamster
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • DDK
    • His
    • HIS
    • Avi
    • GST
    • HA
    • human
    • IgG1
    • Fc
    • MIgG1 Fc
    • MlgG1 Fc
    • MYC/DDK
    • N/A
    • Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PCSK9-86H Recombinant Human PCSK9 Protein, His-tagged NS0 His
    Human PCSK9-01H Recombinant Human PCSK9 Protein, His-tagged HEK293 cells His
    Mouse Pcsk9-020M Recombinant Mouse Pcsk9 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PCSK9-02H Recombinant Human PCSK9 Protein, His-tagged E.coli His
    Mouse Pcsk9-209M Recombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human PCSK9-289H Recombinant Human PCSK9 (R194A) protein, His-tagged HEK293 His
    Human PCSK9-350H Recombinant Human PCSK9 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human PCSK9-351H Recombinant Human PCSK9 protein, Strep-tagged HEK293 Strep
    Human PCSK9-352H Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Rhesus PCSK9-486R Recombinant Rhesus PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged HEK293 MIgG1 Fc
    Human PCSK9-692H Recombinant Human PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged HEK293 MIgG1 Fc
    Mouse PCSK9-812M Recombinant Mouse PCSK9 Protein (Met1-Gln694), MlgG1 Fc-tagged HEK293 MlgG1 Fc
    Human PCSK9-1154H Recombinant Human PCSK9 protein, His-tagged E.coli His
    Human PCSK9-153H Recombinant Human PCSK9, HIS/HA/AVI-tagged HEK293 His/HA/Avi
    Human PCSK9-168H Recombinant Human PCSK9 Protein, DDK/HIS-tagged HEK293 DDK/His
    Human PCSK9-169H Recombinant Human PCSK9 Protein, HIS-tagged CHO HIS
    Human PCSK9-186H Recombinant Human PCSK9, His-tagged, Biotinylated HEK293 His
    Human PCSK9-187H Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human PCSK9-201H Recombinant Human PCSK9, His-tagged, C13&N15 Labeled HEK293 His
    Human PCSK9-2137H Recombinant Human PCSK9 (D374Y) protein, His-tagged HEK293 His
    Human PCSK9-242H Recombinant Human PCSK9, C13&N15-labeled HEK293 N/A
    Human PCSK9-2875HCL Recombinant Human PCSK9 cell lysate Human Cell N/A
    Human PCSK9-312H Recombinant Human PCSK9 protein, His-tagged HEK293 His
    Human PCSK9-643H Recombinant Human Mature PCSK9 protein, His-tagged HEK293 His
    Mouse Pcsk9-1155M Recombinant Mouse Pcsk9 protein, His & GST-tagged E.coli His/GST
    Mouse Pcsk9-197M Recombinant Mouse Pcsk9, His-tagged, C13&N15 Labeled HEK293 His
    Mouse Pcsk9-243M Recombinant Mouse Pcsk9, C13&N15-labeled HEK293 N/A
    Mouse PCSK9-2564MCL Recombinant Mouse PCSK9 cell lysate Human Cell N/A
    Mouse Pcsk9-259M Recombinant Mouse Pcsk9 protein, His-tagged NS0 His
    Mouse Pcsk9-663M Recombinant Mouse Pcsk9 protein, His-tagged HEK293 His
    Rat Pcsk9-1156R Recombinant Rat Pcsk9 protein, His & GST-tagged E.coli His/GST
    Rat PCSK9-2306RCL Recombinant Rat PCSK9 cell lysate Human Cell N/A
    Rat PCSK9-4311R Recombinant Rat PCSK9 Protein Mammalian Cell His
    Rat Pcsk9-915R Recombinant Rat Pcsk9 protein, His-tagged HEK293 His
    Cynomolgus PCSK9-358C Recombinant Cynomolgus PCSK9 protein, His-tagged HEK293 His
    Rhesus Macaque PCSK9-2775RCL Recombinant Rhesus PCSK9 cell lysate Human Cell N/A
    Rhesus macaque PCSK9-311R Recombinant Rhesus macaque PCSK9 protein, His-tagged HEK293 His
    Rhesus Macaque PCSK9-3334R Recombinant Rhesus monkey PCSK9 Protein, His-tagged Mammalian Cell His
    Hamster PCSK9-313H Recombinant Hamster PCSK9 protein, His-tagged HEK293 His
    Kit-0665 PCSK9-BIRC2 in vitro Binding Assay Kit N/A
    Kit-0666 PCSK9-LDLR in vitro Binding Assay Kit N/A
    Kit-1806 PCSK9(D374T)-LDLR TR-FRET Assay Kit N/A
    Kit-1807 PCSK9[Biotinylated]-LDLR Binding Assay Kit N/A
    Kit-1808 PCSK9-LDLR TR-FRET Assay Kit N/A

    PCSK9 involved in several pathways and played different roles in them. We selected most pathways PCSK9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PCSK9 has several biochemical functions, for example, apolipoprotein binding, apolipoprotein receptor binding, low-density lipoprotein particle binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK9 itself. We selected most functions PCSK9 had, and list some proteins which have the same functions with PCSK9. You can find most of the proteins on our site.

    Function Related Protein
    apolipoprotein binding PLG; VLDLR; LPL; ABCA1; LIPC; LRP6; LPA; LRP4; CANX; PCSK9
    apolipoprotein receptor binding PCSK9; APOA2; APOA1
    low-density lipoprotein particle binding MSR1; SCARB1; CRP; ANKRA2; PCSK9; COLEC12; SORL1; LIPC; LDLR; THBS1
    low-density lipoprotein particle receptor binding HSP90B1; LRP2; LRPAP1; DNAJA1; SACS; APOA5; SYT1; SLC9A3R2; LANCL1; APOEA
    poly(A) RNA binding MKRN1; CKAP4; SEC23IP; ZCCHC17; STRBP; LTA4H; LARP4B; MCAT; PDAP1; SPATS2L
    protein binding ZNF230; SECISBP2; CTSG; CDKN1A; LARP7; FGF3; HOOK2; CPSF4; PHYHIPL; VAV2
    protein self-association TTN; DVL2; AGTR1B; RYR2; NKX3; SLC9A3R1; CTSC; NKX3-1; LDB1; AGA
    receptor inhibitor activity PCSK9
    serine-type endopeptidase activity KLK4; CELA3A; PRSS58; HGF; FAP; F9A; KLK13; PRSS2; MST1; KLK9
    sodium channel inhibitor activity CAMK2D; SLC14A2; NEDD4L; SCN1B; NEDD4; PCSK9
    very-low-density lipoprotein particle binding VLDLR; PCSK9
    very-low-density lipoprotein particle receptor binding APOEB; APOEA; Reln; PCSK9; APOE; LRPAP1

    PCSK9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK9 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK9.

    LDLR; MMP2; ANXA2

    Shapiro, MD; Fazio, S; et al. Targeting PCSK9 for Therapeutic Gains. CURRENT ATHEROSCLEROSIS REPORTS 17:-(2015).
    Tavori, H; Giunzioni, I; et al. PCSK9 inhibition to reduce cardiovascular disease risk: recent findings from the biology of PCSK9. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY 22:126-132(2015).

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