sirpa
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  • Official Full Name
  • signal-regulatory protein alpha
  • Background
  • plays a role in macrophage fusion
  • Synonyms
  • SIRPA; signal-regulatory protein alpha; tyrosine-protein phosphatase non-receptor type substrate 1; mSIRP-alpha1; sirp-alpha-1; myD-1 antigen; SHP substrate 1; inhibitory receptor SHPS-1; signal-regulatory protein alpha-1; CD172 antigen-like family member A; brain immunological-like with tyrosine-based motifs; protein tyrosine phosphatase, non-receptor type substrate 1; brain Ig-like molecule with tyrosine-based activation motifs; Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
Cat.#:SIRPA-808HTag:Fc-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA Protein, Fc-Avi-tagged, Biotinylated
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Cat.#:SIPRA-4843HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA protein, His-tagged
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Cat.#:SIRPA-170HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SIRPA Protein, Fc-tagged, Biotinylated
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Cat.#:SIRPA-202HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SIRPA protein, Fc-tagged
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Cat.#:SIRPA-2678HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRPA, His-tagged
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Cat.#:SIRPA-3218HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA, His tagged
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Cat.#:SIRPA-4849HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA protein, His-tagged
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Cat.#:SIRPA-806HTag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human SIRPA Protein, Fc Chimera
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Cat.#:SIRPA-807HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA protein, Fc-tagged
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Cat.#:Sirpa-5667MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirpa protein, His & T7-tagged
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Cat.#:SIRPA-936MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SIRPA Protein, Fc-tagged
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Cat.#:SIRPA-937MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SIRPA Protein, His-tagged
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Cat.#:Sirpa-195RTag:His
Source (Host):Insect cellSpecies:Rat
Product nameRecombinant Rat Sirpa protein, His-tagged
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Cat.#:Sirpa-23RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Sirpa, His tagged
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Cat.#:SIRPA-5407RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIRPA Protein
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Cat.#:Sirpa-5668RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirpa protein, His & T7-tagged
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Cat.#:SIRPA-3300CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRPA
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Cat.#:SIRPA-2298HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRPA cell lysate
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Cat.#:SIRPA-1650MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SIRPA cell lysate
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Cat.#:SIRPA-1005RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SIRPA cell lysate
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Involved Pathway

SIRPA involved in several pathways and played different roles in them. We selected most pathways SIRPA participated on our site, such as BDNF signaling pathway, Cardiac Progenitor Differentiation, Cell surface interactions at the vascular wall, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
CDK5; LINGO1; BCL2L11; SYN1; DOK5; CNR1; CDH2; CDKL5; FRS3; FRS2
Cardiac Progenitor Differentiation
NKX2; SOX1; NIPAL1; LIN28B; TBX5; ROR2; NOG; T; ZFP42; LIN28A
Cell surface interactions at the vascular wall
SLC7A8A; CEACAM8; MERTK; CD84; SLC7A11; CD177; CEACAM1; NADL1.1; ITGB1B.1; CEACAM6
Cell-Cell communication
CDH6; KIRREL3; CDH18; PVRL2L; CADM2B; CDH12A; KIRREL3L; SIRPA; CDH13; CDH24
Hemostasis
RAPGEF4; HBG2; CENPE; HRG; ANXA2B; HBB-BH1; DOCK9; CABLES1; PLEK; SIRPA
IL-1 Signaling Pathway
SIRPA; IL1RN; IKBKAP
Osteoclast differentiation
SIRPA; TYROBP; BLNK; NFKB2; TRAF2; PPP3R1; LILRA5; NCF4; CALCR; SIRP-BETA
Prolactin Signaling Pathway
RELA; INS2; SHC1; FOXO3; GALT; KRAS; STAT5B; PIK3R2; TNFSF11; AKT2

Protein Function

SIRPA has several biochemical functions, for example, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRPA itself. We selected most functions SIRPA had, and list some proteins which have the same functions with SIRPA. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein GRB2; NOXA1; SOS1; WAS; USP8; INPPL1B; QKIA; SKAP1; CASP9; QKI

Interacting Protein

SIRPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRPA here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRPA.
NOL3; PTPN6; TRIM2; HTT; GRB2