TMPRSS2
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Official Full Name
transmembrane protease, serine 2
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Overview
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10; Transmembrane protease, serine 2, EC 3.4.219; D16Ertd61e; Epitheliasin; FLJ41954; MGC6821; PP9284; Serine protease 10; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293F
- Human cells
- In Vitro Cell Free System
- Mammalian cell
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- Myc
- His|T7
- SUMO
- sumostar
- MBP
- Avi
- N/A
- N
- FLAG
- C
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | TMPRSS2-4595H | Active Recombinant Human TMPRSS2 protein, His-tagged | Yeast | His | 106-492aa | |
Human | TMPRSS2-1856H | Recombinant Human TMPRSS2 Protein (106-492 aa), His-tagged | Yeast | His | 106-492 aa | |
Human | TMPRSS2-30144TH | Recombinant Human TMPRSS2 | Wheat Germ | N/A | 110 amino acids | |
Human | TMPRSS2-8077H | Recombinant Human TMPRSS2 protein, His-tagged | E.coli | His | Ser284~Gly492 | |
Human | TMPRSS2-4899H | Recombinant Human TMPRSS2 protein, His-tagged | HEK293 | His | 106-492 aa | |
Human | TMPRSS2-910HCL | Recombinant Human TMPRSS2 293 Cell Lysate | HEK293 | N/A | ||
Human | TMPRSS2-123H | Recombinant Human TMPRSS2 Protein | E.coli | |||
Human | TMPRSS2-427H | Recombinant Human TMPRSS2 Protein, His-tagged | E.coli | N-His | Trp106-Gly492 | |
Human | TMPRSS2-70H | Recombinant Human TMPRSS2 protein, GST-tagged | Wheat Germ | GST | ||
Human | TMPRSS2-4596H | Recombinant Human TMPRSS2 protein, His-sumostar-tagged | Yeast | His-sumostar | 106-492aa | |
Human | TMPRSS2-6469H | Recombinant Human TMPRSS2 Protein (Ser284-Gly492), His tagged | E.coli | His | Ser284-Gly492 | |
Human | TMPRSS2-02H | Active Recombinant Human TMPRSS2 Protein, His-tagged | Mammalian cell | His | 106-492 | |
Human | TMPRSS2-01H | Recombinant Human TMPRSS2 protein | E.coli | |||
Human | TMPRSS2-4598H | Recombinant Human TMPRSS2 protein, His-tagged | Mammalian cell | His | 106-492aa (R255Q) | |
Human | TMPRSS2-086H | Recombinant Human TMPRSS2 Protein, His-tagged | Human cells | His | ||
Human | TMPRSS2-4591H | Recombinant Human TMPRSS2 protein, His-tagged | E.coli | His | 106-492aa | |
Human | TMPRSS2-4597H | Recombinant Human TMPRSS2 protein, His&Myc-tagged | Mammalian cell | His&Myc | 106-492aa | |
Human | TMPRSS2-6852HF | Recombinant Full Length Human TMPRSS2 Protein, GST-tagged | In Vitro Cell Free System | GST | 492 amino acids | |
Human | TMPRSS2-4599H | Recombinant Human TMPRSS2 protein, His-sumostar-tagged | Yeast | His-sumostar | 106-492aa (R255Q) | |
Human | TMPRSS2-4592H | Recombinant Human TMPRSS2 protein, MBP&His-Avi-tagged | E.coli | MBP&His-Avi | 106-492aa | |
Human | TMPRSS2-13H | Recombinant Active Human TMPRSS2 Protein (107-492), N-FLAG and C-Myc/His-tagged | HEK293F | N-FLAG and C-Myc/His | 107-492 | |
Human | TMPRSS2-05944H | Recombinant Human TMPRSS2 Protein(256-492aa), GST-tagged | E. coli | N-GST | 256-492aa | |
Human | TMPRSS2-05943H | Recombinant Human TMPRSS2 Protein(106-492aa), MBP&His-Avi-tagged, Biotinylated | E. coli | N-MBP&C-His-Avi | 106-492aa | |
Human | TMPRSS2-4593H | Recombinant Human TMPRSS2 protein, His-SUMO-tagged | E.coli | His-SUMO | 106-492aa | |
Human | TMPRSS2-4594H | Recombinant Human TMPRSS2 protein, GST-tagged | E.coli | GST | 106-492aa | |
Mouse | Tmprss2-8078M | Recombinant Mouse Tmprss2 protein, His & T7-tagged | E.coli | His/T7 | Ile254~Ser490 (Accession # Q9JIQ8) | |
Mouse | Tmprss2-4893M | Recombinant Mouse Tmprss2 protein, His-tagged | HEK293 | His | 105-490 aa | |
Mouse | Tmprss2-428M | Recombinant Mouse Tmprss2 Protein, His-tagged | E.coli | N-His | Trp105-Ser490 | |
Rat | Tmprss2-429R | Recombinant Rat Tmprss2 Protein, His-tagged | E.coli | N-His | Lys106-Ser490 | |
Zebrafish | TMPRSS2-1912Z | Recombinant Zebrafish TMPRSS2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TMPRSS2 Related Articles
TMPRSS2 involved in several pathways and played different roles in them. We selected most pathways TMPRSS2 participated on our site, such as Influenza A, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPRSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Influenza A | MAPK1;HLA-DMB;PRKCB;FAS;IFNA16;OAS1B;STAT2;MAP2K4;CCL5 |
Transcriptional misregulation in cancer | ELK4;HIST1H3C;SPI1;LYL1;SSX1;TCF3;MET;SIX4;LMO2 |
TMPRSS2 has several biochemical functions, for example, protein binding, scavenger receptor activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TMPRSS2 itself. We selected most functions TMPRSS2 had, and list some proteins which have the same functions with TMPRSS2. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | SSBP1;C11orf57;KMT2E;RAP1GAP;PITX2;NR1H2;APC;DNER;LATS2 |
scavenger receptor activity | SRCRB4D;MARCO;PRSS12;TMPRSS4A;ENDOU;CXCL16;LGALS3BPA;TMPRSS15;PRSS7 |
serine-type endopeptidase activity | PRSS22;RHBDD1;C1RA;KLK8;F9B;HTRA3A;KLK1B4;FAP;PARL |
serine-type peptidase activity | PCSK5B;DPP9;Gzmg;PRSS40;F7;KLK1B9;KLK1B1;Prss32;PRTN3 |
TMPRSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPRSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPRSS2.
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, transcription factors and signaling pathways have been identified that are associated with the regulation of the expression of TMPRSS2 proteins, which regulate the expression levels and activity of TMPRSS2 proteins.
TMPRSS2 protein can be used to aid the diagnosis of certain tumors. Measuring the expression level of TMPRSS2 proteins in tumor tissues can be used as an auxiliary marker to determine disease type and prognosis.
TMPRSS2 proteins play an important role in some viral infections. For example, in novel coronavirus (SARS-CoV-2) infection, TMPRSS2 proteins facilitate the entry of the virus into host cells.
Yes, proteins that interact with TMPRSS2 proteins have been discovered, including viral proteins, cell surface receptors, etc. These interactions are involved in biological processes such as viral invasion and cell signaling.
Research on TMPRSS2 protein is going on. At present, it mainly focuses on the analysis of its function, the identification of gene mutations associated with diseases, and the interaction with other proteins, providing a theoretical basis for further understanding of diseases related to TMPRSS2 proteins.
Some studies have shown that high expression of TMPRSS2 protein in lung cancer may be associated with a poorer prognosis. However, the specific mechanisms need to be further studied to confirm.
Customer Reviews (3)
Write a reviewStable and did not change significantly during storage and transportation.
High solubility makes it easy to prepare the desired concentration.
The protein had good crystallinity, which was beneficial for crystallographic study.
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