TMPRSS2 Protein, transmembrane protease, serine 2

TMPRSS2

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TMPRSS2

Official Full Name transmembrane protease, serine 2
Background This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10; Transmembrane protease, serine 2, EC 3.4.219; D16Ertd61e; Epitheliasin; FLJ41954; MGC6821; PP9284; Serine protease 10; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TMPRSS2-01H Recombinant Human TMPRSS2 protein E.coli
    Human TMPRSS2-70H Recombinant Human TMPRSS2 protein, GST-tagged Wheat Germ GST
    Human TMPRSS2-02H Recombinant Human TMPRSS2 Protein, His-tagged Mammalian cell His
    Human TMPRSS2-1856H Recombinant Human TMPRSS2 Protein (106-492 aa), His-tagged Yeast His
    Human TMPRSS2-30144TH Recombinant Human TMPRSS2 Wheat Germ N/A
    Human TMPRSS2-4899H Recombinant Human TMPRSS2 protein, His-tagged HEK293 His
    Human TMPRSS2-8077H Recombinant Human TMPRSS2 protein, His-tagged E.coli His
    Human TMPRSS2-910HCL Recombinant Human TMPRSS2 293 Cell Lysate HEK293 N/A
    Mouse Tmprss2-4893M Recombinant Mouse Tmprss2 protein, His-tagged HEK293 His
    Mouse Tmprss2-8078M Recombinant Mouse Tmprss2 protein, His & T7-tagged E.coli His/T7
    Zebrafish TMPRSS2-1912Z Recombinant Zebrafish TMPRSS2 Mammalian Cell His

    TMPRSS2 involved in several pathways and played different roles in them. We selected most pathways TMPRSS2 participated on our site, such as Influenza A, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPRSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Influenza A Ifna15; IFN-a; TLR4; HLA-DPA1; NXT1; IKBKE; LOC100033925; TNFRSF10D; H2-AA; BLB2
    Transcriptional misregulation in cancer PML; LMO2; MPO; EWSR1; HIST3H3; LYL1; DEFA3; BCL2A1A; PTCRA; SIN3A

    TMPRSS2 has several biochemical functions, for example, protein binding, scavenger receptor activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TMPRSS2 itself. We selected most functions TMPRSS2 had, and list some proteins which have the same functions with TMPRSS2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NUMB; CCDC120; PES1; EIF1AX; RIN1; TGS1; TEKT4; FBXO3; EIF1AD; GNE
    scavenger receptor activity SCART1; LOXL2; PRSS12; MSR1; LGALS3BPB; LOXL3; SCARF1; C8orf84; ENPP1; TMPRSS15
    serine-type endopeptidase activity CFI; CTSC; FURINA; F9; F9B; TPSAB1; LOC780933; RHBDD1; PRTN3; PCSK5
    serine-type peptidase activity KLK1B11; HPN; KLK1B1; HTRA1; TMPRSS11E; MCPT9; SEC11A; KLK7; KLK10; KLK1B5

    TMPRSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPRSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPRSS2.

    Gierer, S; Muller, MA; et al. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. JOURNAL OF INFECTIOUS DISEASES 211:889-897(2015).
    Yang, F; Chen, YZ; et al. Stromal TGF-beta signaling induces AR activation in prostate cancer. ONCOTARGET 5:10854-10869(2014).

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