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Tnfsf4

  • Official Full Name

    tumor necrosis factor (ligand) superfamily, member 4

  • Overview

    OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
  • Synonyms

    TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l; CD134L; CD 252; CD134; CD134 ligand; CD134L; CD252; CD252 antigen; glycoprotein 34 kd; glycoprotein Gp34; GP34; OX-40L; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFL4; TNFSF4; tumor necrosis factor ligand superfamily member 4; TXGP1; tumor necrosis factor (ligand) superfamily, member 4;

  • Recombinant Proteins
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus macaque
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rabbit
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Hi-5 Insect Cell
  • Human Cell
  • Human Cells
  • Insect cell
  • Insect Cell
  • Mammalian cells
  • Avi
  • Fc
  • C
  • His
  • Myc
  • DDK
  • Fc|His
  • Flag
  • hFc
  • His (Fc)
  • human|IgG1|Fc
  • mFc
  • MIgG1 Fc
  • Myc|DDK
  • N/A
  • N
  • 6×His
  • RlgG Fc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFSF4-27254TH Active Recombinant Human TNFSF4 Hi-5 Insect Cell N/A
Human TNFSF4-272H Active Recombinant Human TNFSF4, His-tagged HEK293 His
Human TNFSF4-490H Recombinant Human TNFSF4 protein, Fc-tagged HEK293 human/IgG1/Fc Gln51-Leu183
Human TNFSF4-344H Active Recombinant Human TNFSF4 protein, mFc-tagged HEK293 mFc Gln 51 - Leu 183
Human TNFSF4-2259H Recombinant Human TNFSF4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFSF4-886M Recombinant Mouse TNFSF4 Protein (Gln49-Leu198), MIgG1 Fc-tagged HEK293 MIgG1 Fc Gln49-Leu198
Human TNFSF4-491HAF647 Recombinant Human TNFSF4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Gln51-Leu183, 412
Human TNFSF4-880HG Active GMP Recombinant Human TNFSF4 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human OX40 ligand(NCBI Reference Sequence: NP_003317.1) was expressed with Fc tag at the C-terminal.
Human TNFSF4-490HAF555 Recombinant Human TNFSF4 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Gln51-Leu183
Human TNFSF4-086H Recombinant Human TNFSF4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human TNFSF4-191H Recombinant Human TNFSF4 Protein, His-tagged Human Cells His
Human TNFSF4-491HAF555 Recombinant Human TNFSF4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Gln51-Leu183, 412
Human TNFSF4-490HAF647 Recombinant Human TNFSF4 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Gln51-Leu183
Human TNFSF4-490HAF488 Recombinant Human TNFSF4 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Gln51-Leu183
Human TNFSF4-142H Recombinant Human TNFSF4 Protein, His-tagged E.coli His
Human TNFSF4-1935HFL Recombinant Full Length Human TNFSF4 Protein, C-Flag-tagged Mammalian cells Flag
Human TNFSF4-490HF Recombinant Human TNFSF4 Protein, hFc-tagged, FITC conjugated HEK293 hFc Gln51-Leu183
Human TNFSF4-491HAF488 Recombinant Human TNFSF4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Gln51-Leu183, 412
Human TNFSF4-2223H Recombinant Human TNFSF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFSF4-5153H Recombinant Human TNFSF4 Protein (Leu29-Ala216), C-His tagged Mammalian cells C-His Leu29-Ala216
Human TNFSF4-491HF Recombinant Human TNFSF4 Protein, Fc-tagged, FITC conjugated HEK293 Fc Gln51-Leu183, 412
Human TNFSF4-78H Recombinant Human TNFSF4 Protein, His-tagged Human Cell His
Human TNFSF4-2223H-B Recombinant Human TNFSF4 Protein Pre-coupled Magnetic Beads HEK293
Human TNFSF4-0588H Active Recombinant Human TNFSF4 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln51-Leu183
Human TNFSF4-688H Recombinant Human TNFSF4 Protein HEK293 183
Human TNFSF4-0589H Active Recombinant Human TNFSF4 protein, Fc-tagged HEK293 Fc Gln51-Leu183
Human TNFSF4-0924H Recombinant Human TNFSF4 Protein (Gln51-Leu183), N-His tagged E.coli N-His Gln51-Leu183
Human TNFSF4-0590H Active Recombinant Human TNFSF4 protein, Avi-Fc-tagged, Biotinylated HEK293 Avi-Fc Gln51-Leu183
Human TNFSF4-689H Recombinant Human TNFSF4 Protein, Fc-tagged HEK293 Fc 183
Human TNFSF4-5152H Recombinant Human TNFSF4 Protein (Leu29-Ala216), N-Fc tagged Mammalian cells N-Fc Leu29-Ala216
Human TNFSF4-682H Recombinant Human TNFSF4 Protein (Gln51-Leu183), N-mFc and C-6×His-tagged HEK293 N-mFc and C-6×His Gln51-Leu183
Human TNFSF4-5150H Recombinant Human TNFSF4 Protein (Gln51-Leu183), N-His tagged Mammalian cells N-His Gln51-Leu183
Mouse Tnfsf4-21M Active Recombinant Mouse Tnfsf4 protein, His-tagged HEK293 His Gln49-Leu198
Mouse Tnfsf4-407M Active Recombinant Mouse Tnfsf4, FLAG-tagged HEK293 Flag
Mouse Tnfsf4-20M Recombinant Mouse Tnfsf4 protein, Fc-tagged HEK293 human/IgG1/Fc Gln49-Leu198
Mouse Tnfsf4-2074M Recombinant Mouse Tnfsf4, FLAG-tagged HEK293 Flag
Mouse Tnfsf4-90M Active Recombinant Mouse Tnfsf4 Protein (Gln49-Leu198), N-His tagged, Animal-free, Carrier-free E.coli N-His Gln49-Leu198
Mouse Tnfsf4-01M Active Recombinant Mouse Tnfsf4 Protein, His-tagged Insect cell His 51-198aa
Mouse TNFSF4-690M Recombinant Mouse TNFSF4 Protein, Fc-tagged HEK293 Fc 198
Mouse Tnfsf4-6762M Recombinant Mouse Tnfsf4 Protein (Ser51-Leu198), N-His tagged Mammalian cells N-His Ser51-Leu198
Mouse Tnfsf4-6557M Recombinant Mouse Tnfsf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnfsf4-456M Active Recombinant Mouse Tnfsf4 protein, His-tagged HEK293 His Ser51-Leu198
Mouse TNFSF4-887M Recombinant Mouse TNFSF4 Protein (Gln49-Leu198), RlgG Fc-tagged HEK293 RlgG Fc Gln49-Leu198
Mouse TNFSF4-84M Recombinant Mouse TNFSF4 Protein, His-tagged Human Cell His Ser51-Leu198
Rat TNFSF4-6204R Active Recombinant Rat TNFSF4 protein, His-tagged HEK293 His Gln 49 - Leu 199
Rat TNFSF4-5861R-B Recombinant Rat TNFSF4 Protein Pre-coupled Magnetic Beads HEK293
Rat TNFSF4-5861R Recombinant Rat TNFSF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey TNFSF4-67CAF555 Recombinant Monkey TNFSF4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 369
Monkey TNFSF4-67CAF647 Recombinant Monkey TNFSF4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 369
Monkey TNFSF4-67CAF488 Recombinant Monkey TNFSF4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 369
Monkey TNFSF4-67CF Recombinant Monkey TNFSF4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 369
Rabbit TNFSF4-1478R Recombinant Rabbit TNFSF4 protein, hFc-tagged HEK293 hFc 45-187aa
Rabbit TNFSF4-0587R Active Recombinant Rabbit TNFSF4 protein, His-tagged HEK293 His Gln45-Pro187
Rabbit TNFSF4-1526R Recombinant Rabbit TNFSF4 protein, His&Myc-tagged Insect Cell His&Myc 45-187aa
Cynomolgus Monkey TNFSF4-85C Active Recombinant Cynomolgus TNFSF4, Fc-tagged Human Cell Fc
Cynomolgus Monkey TNFSF4-67C Recombinant Cynomolgus TNFSF4, Fc tagged Human Cell Fc/His
Cynomolgus Monkey TNFSF4-857CCL Recombinant Cynomolgus TNFSF4 cell lysate Human Cell N/A
Cynomolgus/Rhesus macaque TNFSF4-0586C Active Recombinant Cynomolgus/Rhesus macaque TNFSF4 protein, His-tagged HEK293 His Gln51-Leu183
Cynomolgus/Rhesus macaque TNFSF4-345R Active Recombinant Cynomolgus/Rhesus macaque TNFSF4 protein, mFc-tagged HEK293 mFc Gln 51 - Leu 183
Homo sapiens (Human) RFL34357HF Recombinant Full Length Human Tumor Necrosis Factor Ligand Superfamily Member 4(Tnfsf4) Protein, His-Tagged E.coli expression system His Full Length (1-183)
Macaca mulatta (Rhesus macaque) TNFSF4-5542M Recombinant Rhesus macaque TNFSF4 Protein (Gln51-Leu183), N-His tagged Mammalian cells N-His Gln51-Leu183
Mus musculus (Mouse) RFL9504MF Recombinant Full Length Mouse Tumor Necrosis Factor Ligand Superfamily Member 4(Tnfsf4) Protein, His-Tagged E.coli expression system His Full Length (1-198)
Oryctolagus cuniculus (Rabbit) RFL29086OF Recombinant Full Length Rabbit Tumor Necrosis Factor Ligand Superfamily Member 4(Tnfsf4) Protein, His-Tagged E.coli expression system His Full Length (1-187)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tnfsf4 Related Articles
  • Tnfsf4 Related Gene Family
  • Tnfsf4 Related Research Area
  • Tnfsf4 Related Signal Pathway

Tnfsf4 involved in several pathways and played different roles in them. We selected most pathways Tnfsf4 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfsf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCLCF1;CNTFR;INHBC;IFNGR2;CXCR3.2;IFNA8;TNFRSF4;Ccl27a;EDA

Tnfsf4 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfsf4 itself. We selected most functions Tnfsf4 had, and list some proteins which have the same functions with Tnfsf4. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTXLNA;INHBA;IL36G;IL33;Fasl;AREG;IL23;INHBB;IL12BA
receptor bindingPAOX;CHRNA10;NOS2;PLAT;SLC27A2;FGG;MYO1C;TIGIT;FGF18A
tumor necrosis factor receptor bindingTNFSF4;FADD;EDA;TNFSF13B;TNFSF9;TRIM37;CD40LG;TNFSF15;TNFSF10L
tumor necrosis factor receptor superfamily bindingTNFSF11;TNFSF4;FADD;TNFSF18;TNFSF9

Tnfsf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfsf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfsf4.

Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do genetic variations in TNFSF4 affect immune function? 01/09/2022

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation? 08/16/2021

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses? 05/11/2020

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders? 09/12/2019

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system? 06/09/2019

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases? 10/04/2018

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation? 03/29/2017

Altered TNFSF4 activity contributes to chronic inflammation.

Customer Reviews (3)

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Reviews
12/28/2022

    Efficient service, accelerates research productivity.

    05/13/2018

      Outstanding accuracy, essential for research quality.

      02/12/2018

        Trusted for research integrity, a critical research asset.

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