Tnfsf4
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 4
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Overview
OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases. -
Synonyms
TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l; CD134L; CD 252; CD134; CD134 ligand; CD134L; CD252; CD252 antigen; glycoprotein 34 kd; glycoprotein Gp34; GP34; OX-40L; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFL4; TNFSF4; tumor necrosis factor ligand superfamily member 4; TXGP1; tumor necrosis factor (ligand) superfamily, member 4;
- Recombinant Proteins
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Cynomolgus Monkey
- Cynomolgus/Rhesus macaque
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Monkey
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rabbit
- Rat
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Hi-5 Insect Cell
- Human Cell
- Human Cells
- Insect cell
- Insect Cell
- Mammalian cells
- Avi
- Fc
- C
- His
- Myc
- DDK
- Fc|His
- Flag
- hFc
- His (Fc)
- human|IgG1|Fc
- mFc
- MIgG1 Fc
- Myc|DDK
- N/A
- N
- 6×His
- RlgG Fc
- Involved Pathway
- Protein Function
- Interacting Protein
- Tnfsf4 Related Articles
- Tnfsf4 Related Gene Family
- Tnfsf4 Related Research Area
- Tnfsf4 Related Signal Pathway
Tnfsf4 involved in several pathways and played different roles in them. We selected most pathways Tnfsf4 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfsf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CLCF1;CNTFR;INHBC;IFNGR2;CXCR3.2;IFNA8;TNFRSF4;Ccl27a;EDA |
Tnfsf4 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfsf4 itself. We selected most functions Tnfsf4 had, and list some proteins which have the same functions with Tnfsf4. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | TXLNA;INHBA;IL36G;IL33;Fasl;AREG;IL23;INHBB;IL12BA |
receptor binding | PAOX;CHRNA10;NOS2;PLAT;SLC27A2;FGG;MYO1C;TIGIT;FGF18A |
tumor necrosis factor receptor binding | TNFSF4;FADD;EDA;TNFSF13B;TNFSF9;TRIM37;CD40LG;TNFSF15;TNFSF10L |
tumor necrosis factor receptor superfamily binding | TNFSF11;TNFSF4;FADD;TNFSF18;TNFSF9 |
Tnfsf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfsf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfsf4.
- Q&As
- Reviews
Q&As (7)
Ask a questionGenetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.
TNFSF4 (OX40L) regulates immune responses and T-cell activation.
It activates T-cells, stimulating inflammatory cytokine production.
TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.
TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.
Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.
Altered TNFSF4 activity contributes to chronic inflammation.
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