Active Recombinant Human FGF23 Protein

Cat.No. : FGF23-036H
Product Overview : The mature recombinant human FGF-23 protein consists of 148 amino acids (25-251) without tag was expressed in E. coli.
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Description : This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
Source : E. coli
Species : Human
Bio-activity : Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 50-300 ng/mL.
Molecular Mass : 26 kDa
Product-Related Proteins : 25-251
Endotoxin : < 0.1 EU/μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Gene Name : FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ]
Official Symbol : FGF23
Synonyms : FGF23; fibroblast growth factor 23; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC; fibroblast growth factor 23; phosphatonin; tumor-derived hypophosphatemia inducing factor
Gene ID : 8074
mRNA Refseq : NM_020638
Protein Refseq : NP_065689
MIM : 605380
UniProt ID : Q9GZV9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does FGF23 play in chronic kidney disease? 06/12/2022

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health? 04/04/2022

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis? 03/24/2022

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity? 01/27/2022

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels? 05/16/2020

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted? 04/28/2020

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body? 10/29/2019

FGF23 regulates phosphate and vitamin D metabolism.

Customer Reviews (3)

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Reviews
07/23/2022

    Excellent results, high purity.

    07/17/2021

      Reliable and effective product.

      11/26/2020

        Quick delivery, product works.

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