Recombinant Human FGF23 Protein, Myc/DDK-tagged, C13 and N15-labeled
|Product Overview :||FGF23 MS Standard C13 and N15-labeled recombinant protein (NP_065689) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).|
|Molecular Mass :||28 kDa|
|AA Sequence :||MLGARLRLWVCALCSVCSMSVLRAY PNASPLLGSSWGGLIHLYTATARNS YHLQIHKNGHVDGAPHQTIYSALMI RSEDAGFVVITGVMSRRYLCMDFRG NIFGSHYFDPENCRFQHQTLENGYD VYHSPQYHFLVSLGRAKRAFLPGMN PPPYSQFLSRRNEIPLIHFNTPIPR RHTRSAEDDSERDPLNVLKPRARMT PAPASCSQELPSAEDNSPMASDPLG VVRGGRVNTHAGGTGPEGCRPFAKF ITRTRPLEQKLISEEDLAANDILDY KDDDDKV|
|Purity :||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for 3 months from receipt of products under proper storage and handling conditions.|
|Storage :||Store at -80 centigrade. Avoid repeated freeze-thaw cycles.|
|Concentration :||50 μg/mL as determined by BCA|
|Storage Buffer :||100 mM glycine, 25 mM Tris-HCl, pH 7.3.|
|Gene Name :||FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ]|
|Official Symbol :||FGF23|
|Synonyms :||FGF23; fibroblast growth factor 23; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC; fibroblast growth factor 23; phosphatonin; tumor-derived hypophosphatemia inducing factor|
|Gene ID :||8074|
|mRNA Refseq :||NM_020638|
|Protein Refseq :||NP_065689|
|UniProt ID :||Q9GZV9|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)Write a review
Excellent results, high purity. -
Reliable and effective product. -
Quick delivery, product works. -
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