Active Recombinant Mouse IL23R protein, Fc-tagged
|Product Overview :||Recombinant Mouse IL23R protein (Gly24-Asp372), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293).|
- Gene Information
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|Form :||Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.|
|Bio-activity :||Loaded Mouse IL-23R, Fc Tag on Protein A Biosensor, can bind Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e).|
|Molecular Mass :||The protein has a calculated MW of 66.8 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein Length :||Gly 24 - Asp 372|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>90% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name :||IL23R interleukin 23 receptor [ Homo sapiens ]|
|Official Symbol :||IL23R|
|Synonyms :||IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;|
|Gene ID :||149233|
|mRNA Refseq :||NM_144701|
|Protein Refseq :||NP_653302|
|UniProt ID :||Q5VWK5|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL23R activation promotes Th17 cell differentiation.
IL23R has multiple alternative splicing variants.
IL23R undergoes phosphorylation that affects its stability.
The half-life of IL23R protein in activated T-cells is approximately 48 hours.
MicroRNAs like miR-20a regulate IL23R expression.
IL23R contributes to the release of pro-inflammatory cytokines like IL-17.
IL23R is implicated in autoimmune diseases like Crohn's.
IL23R expression is upregulated during bacterial infection.
IL23R forms heterodimers with IL-12Rβ1.
IL23R activates the JAK-STAT and NF-κB pathways.
Customer Reviews (3)Write a review
High specificity in ELISA. -
Effective in autoimmune models. -
Suitable for receptor binding studies. -
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