Active Recombinant Mouse Mog Protein, His-tagged

• Cat.No.: Mog-02M
• Product Overview: Recombinant Mouse Mog Protein (Gly29-Gly153), with a C-terminal 10-His tag, was expressed in mouse myeloma cell line.

Specification

• Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to act upstream of or within cell adhesion. Located in myelin sheath. Is expressed in brain and cerebellum. Human ortholog(s) of this gene implicated in multiple sclerosis; narcolepsy; and optic neuritis. Orthologous to human MOG (myelin oligodendrocyte glycoprotein).
• Source: Mouse myeloma cell line
• Species: Mouse
• Tag: His
• Bio-activity: Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Mouse MOG, immobilized at 1 μg/mL on a 96-well plate, is able to significantly enhance neurite outgrowth.
• Molecular Mass: 19-29 kDa
• N-terminal Sequence Analysis: Gly29
• Endotoxin: < 0.10 EU/μg of the protein by the LAL method.
• Purity: > 90% by SDS-PAGE with silver staining
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: Mog myelin oligodendrocyte glycoprotein [ Mus musculus (house mouse) ]
• Official Symbol: Mog
• Synonyms: Mog; myelin oligodendrocyte glycoprotein; B230317G11Rik; myelin-oligodendrocyte glycoprotein
• Gene ID: 17441
• mRNA Refseq: NM_010814
• Protein Refseq: NP_034944
• UniProt ID: Q61885

Reviews

11/20/2022

Excellent in protein studies.

03/14/2022

Reliable, efficient, and effective.

11/23/2021

Worked well, great quality.

Q&As

In which cells or tissues is MOG predominantly expressed?

MOG is predominantly expressed on the outer surface of the myelin sheath in the central nervous system.

What role does MOG play in autoimmune demyelinating diseases?

MOG is a target in autoimmune demyelinating diseases, where the immune system mistakenly attacks it, damaging the myelin sheath.

What diagnostic or therapeutic strategies involve MOG in the context of demyelinating diseases?

MOG antibody testing helps diagnose and distinguish different demyelinating diseases, and therapies aim to modulate the immune response to prevent MOG attack.

Are there known genetic mutations or alterations in MOG associated with specific neurological conditions?

There are no widely recognized genetic mutations in MOG associated with neurological conditions, but research is ongoing.

How does MOG contribute to the integrity and function of the myelin sheath?

MOG contributes to myelin integrity, aiding in proper nerve signal transmission.

How is MOG implicated in the pathogenesis of Multiple Sclerosis (MS)?

MOG antibodies are found in a subset of MS patients, but their exact role in MS pathogenesis is still under investigation.

What is the primary function of MOG in the nervous system?

MOG is involved in the maintenance and stability of the myelin sheath in the central nervous system.