| Cat. No.: | TNFRSF17-5253H |
| Product Overview: | RecombinantTNFRSF17 is a disulfide-linked monomer protein consisting of 54 amino acidresidue subunits, and migrates as an approximately 6kDa protein undernon-reducing and reducing conditions in SDS-PAGE. The protein encodedby this gene is a member of the TNF-receptor superfamily, and was lyophilized from a 0.2 μm filtered 30% acetonitrile, 0.1%TFA solution pH 7.5. |
| Description: | TNFRSF17 (B cell maturation) is a nonglycosylated integral membrane typeI protein that is preferentially expressed in mature B lymphocytes.TheN-terminal part of both mouse and human proteins contains a conserved six-cysteine motif. |
| Source: | Human |
| Host: | E. coli |
| Purity: | >95%, asdetermined by SDS-PAGE and HPLC. |
| Sequence: | MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL |
| Molecular Weight: | 6kDa |
| Biological Activity: | TheED(50) was not determined. |
| Endotoxin: | Endotoxincontent was assayed using a LAL gel clot method. Endotoxin level was found tobe less than 0.1 ng/µg(1EU/µg). |
| Reconstitution: | A quickspin of the vial followed by reconstitution in distilled water to aconcentration not less than 0.1 mg/mL. This solution can then be diluted intoother buffers. |
| Storage: | Thelyophilized protein is stable for at least 2 years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquotsat 2°C - 8°C for one month, or at -20°C for six months, with a carrierprotein without detectable loss of activity. Avoid repeated freeze/thawcycles. |
| OfficialSymbol: | TNFRSF17 |
| Pathways: | Cytokine-cytokinereceptor interaction; Intestinal immune network for IgA production |
| Gene Name: | TNFRSF17 tumor necrosis factor receptor superfamily,member 17 [ Homo sapiens ] |
| Synonyms: | TNFRSF17;tumor necrosis factor receptor superfamily, member 17; BCM;BCMA; CD269; tumor necrosis factor receptor superfamily member 17; OTTHUMP00000160261;B-cell maturation factor; B cell maturation antigen; B-cell maturationprotein |
| Gene ID: | 608 |
| mRNA Refseq: | NM_001192 |
| Protein Refseq: | NP_001183 |
| MIM: | 109545 |
| UniProt ID: | Q02223 |
| Chromosome Location: | 16p13 |
| Function: | receptor activity;tumor necrosis factor receptor activity |
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