Active Recombinant Human A2M protein, His-tagged
Cat.No. : | A2M-6857H |
Product Overview : | Recombinant Human A2M protein(NP_000005.2)(Met1-Ala1474), fused with His tag, was expressed in Insect Cells. |
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Source : | Insect Cells |
Species : | Human |
Tag : | His |
Form : | Supplied as sterile 20mM Tris,150mM NaCl, 20% glycerol, pH 7.4Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA. |
Bio-activity : | Measured by its ability to trap trypsin. The trapped trypsin is no longer able to interact with protein substrates or inhibitors, but still able to cleave small peptide substrates or inhibitors.The IC50 value is <5 nM. |
Molecular Mass : | The recombinant human A2M consists of 1461 amino acids and predicts a molecular mass of 164 kDa. The apparent molecular mass of rhA2M is approximately 160-170 kDa in SDS-PAGE under reducing conditions. |
Protein Length : | Met1-Ala1474 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 85 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | A2M alpha-2-macroglobulin [ Homo sapiens ] |
Official Symbol : | A2M |
Synonyms : | A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2MD; S863-7; DKFZp779B086; |
Gene ID : | 2 |
mRNA Refseq : | NM_000014 |
Protein Refseq : | NP_000005 |
MIM : | 103950 |
UniProt ID : | P01023 |
Products Types
◆ Native Protein | ||
A2m-367M | Native Mouse Alpha-2-Macroglobulin | +Inquiry |
A2m-695R | Native Rat Alpha-2-Macroglobulin | +Inquiry |
◆ Lysates | ||
A2M-593HCL | Recombinant Human A2M cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.
Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.
The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.
Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.
A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.
A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.
Customer Reviews (3)
Write a reviewIt can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.
Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.
The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.
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