"GRK5" Related Products


Recombinant Human GRK5 (Active), GST-tagged

Cat.No. : GRK5-1410H
Product Overview : Recombinant full-length human GRK5 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description : GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRK5.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 40 nmol/min/mg
Molecular Mass : ~95 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
Official Symbol : GRK5
Synonyms : GRK5; G protein-coupled receptor kinase 5; GPRK5; FP2025; g protein-coupled receptor kinase GRK5; FLJ39780;
Gene ID : 2869
mRNA Refseq : NM_005308
Protein Refseq : NP_005299
MIM : 600870
UniProt ID : P34947
Chromosome Location : 10q24-qter
Pathway : Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function : ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; phospholipid binding; protein binding; protein kinase C binding; protein serine/threonine kinase activity;

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