| Species : |
Human |
| Source : |
Mouse |
| Tag : |
Non |
| Antigen Description : |
TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock. |
| Target : |
TREM1 |
| Immunogen : |
Recombinant human TREM-1 |
| Isotype : |
IgG2b, kappa |
| species : |
Human |
| Conjugation : |
N/A |
| Applications : |
ELISA,WB,Flow Cyt |
| Preparation : |
The antibody was purified by affinity chromatography. |
| Usage recommendation : |
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 μg per million cells in 100 μl volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Concentration : |
0.5 mg/ml |
| Storage : |
The antibody solution should be stored undiluted at 4 °C. |
| Size : |
25 μg;100 μg |
