Human Alpha-2-Macroglobulin

• Cat.No.: A2M-4176H
• Product Overview: Human A2M is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa.

Specification

• Cat. No.: A2M-4176H
• Description: A2M is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. A2M is a large plasma protein, which is produced by the liver.
• Source: Human
• Host: Human Plasma.
• Form: Lyophilized from 0.02 M TRIS, 0.15 M NaCl and 0.1 M Sucrose, pH 8.0.
• Purity: Greater than 96.0%.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Storage: Human A2M although stable at room temperature for 3 weeks, should be stored between 2-8°C.

Gene Information

• Gene Name: A2M alpha-2-macroglobulin [ Homo sapiens ]
• Official Symbol: A2M
• Synonyms: A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863-7; DKFZp779B086; alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
• Gene ID: 2
• mRNA Refseq: NM_000014
• Protein Refseq: NP_000005
• MIM: 103950
• UniProt ID: P01023
• Chromosome Location: 12p13
• Pathway: Complement and Coagulation Cascades; Formation of Fibrin Clot ; Formation of Platelet plug; HDL-mediated lipid transport; Hemostasis; IL6-mediated signaling events; Intrinsic Pathway; Lipid digestion; Lipoprotein metabolism; Metabolism of lipids and lipoproteins; Platelet Activation; Platelet degranulation; Rho GTPase cycle
• Function: GTPase activator activity; enzyme binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; protein binding; serine-type endopeptidase inhibitor activity; tumor necrosis factor binding