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Recombinant Rat Clu, His-tagged

Cat.No. : Clu-3664R
Product Overview : Total 240 AA. MW: 26.5 kDa (calculated). N-Terminal T7-Tag and C-Terminal His-tag, 25 extra AA (highlighted).
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  • Gene Information
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Cat. No. : Clu-3664R
Description : Clusterin is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the Clu gene.
Source : E. coli
Species : Rat
Form : Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 0.01M Tris pH 7.2.
Research topic : Animal studies; Others; Renal disease; Sepsis
Purity : >95%
Reconstitution : Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications : ELISA, Western blotting
Quality Control Test : BCA to determine quantity of the protein; SDS-PAGE to determine purity of the protein
Sequences of amino acids : MASMTGGQQM GRDPNSSSPF YFWMNGDRID SLLESDRQQS QVLDAMQDSF TRASGIIDTL FQDRFFTHEP QDIHHFSPMG FPHKRPHLLY PKSRLVRSLM PLSHYGPLSF HNMFQPFFDM IHQAQQAMDV QLHSPALQFP DVDFLKEGED DRTVCKEIRH NSTGCLKMKG QCEKCQEILS VDCSTNNPAQ ANLRQELNDS LQVAERLTQQ YNELLHSLQS KMLNTSSLLE QALEHHHHHH
Storage : Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Gene Name : Clu clusterin [ Rattus norvegicus ]
Official Symbol : Clu
Synonyms : Clu; clusterin; CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B; sulfated glycoprotein 2; dimeric acid glycoprotein; testosterone-repressed prostate message; testostrone-repressed prostate message 2; testosterone repressed prostate message 2
Gene ID : 24854
mRNA Refseq : NM_053021
Protein Refseq : NP_444180
UniProt ID : P05371
Chromosome Location : 15p12
Pathway : Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+
Function : NOT ATPase activity; ATPase activity; misfolded protein binding; ubiquitin protein ligase binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CLU contribute to the regulation of inflammation, and what role does it play in immune responses and autoimmunity? 05/03/2022

CLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.

How does CLU contribute to the regulation of cell survival and apoptosis, and what are the molecular mechanisms involved? 03/08/2021

CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.

How does CLU influence cell adhesion and migration, and what role does it play in tissue remodeling and repair processes? 01/16/2020

CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.

Can you discuss the association between CLU and neurodegenerative disorders, and how does it impact the pathogenesis of conditions like Alzheimer's disease? 11/16/2019

CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.

Can you elaborate on the molecular interactions of CLU with lipids and its involvement in lipid transport and metabolism? 07/24/2018

CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.

Customer Reviews (3)

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Reviews
11/30/2021

    Impressed with the quality control. This product is a gem in our lab experiments.

    01/22/2019

      Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.

      04/17/2018

        Our lab manager introduced us to this product, and we're never going back. Essential for our studies.

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