Recombinant Human Beta-Defensin 2 DEFB4-18H

Recombinant Human Beta-Defensin 2

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Recombinant Human Beta-Defensin 2

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Cat. No. : DEFB4-18H
Product Overview : Recombinant Human beta-Defensin 2 produced inE. coliis a single non-glycosylated polypeptide chain containing 41 amino acids and having a molecular mass of 4.3 kDa.
Description : Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
Purity : >98% by SDS-PAGE and HPLC analyses.
Formulation : Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.
Biological Activity : Fully biologically active when compared to standard. Determined by its ability to chemoattract immature human dendritic cells using a concentration range of 10-100 ng/ml.
Endotoxin : Less than 1EU/mg of rHuBD-2 as determined by LAL method.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storagee : This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Process : G-protein coupled receptor protein signaling pathway; chemotaxis; defense response to bacterium; immune response.
PDBrendering based on 1e4q. :

Gene Name : DEFB4
Synonyms : DEFB-2; DEFB102; DEFB2; HBD-2; SAP1; defensin, beta 4; defensin, beta 2; skin-antimicrobial peptide 1; Beta-defensin 2 precursor; Defensin β2; H.sapiens mRNA for skin-antimicrobial-peptide 1 (SAP1); defensin β4; DEFB4
Gene ID : 1673
mRNA Refseq : NM_004942.2
Protein Refseq : NP_004933.1
MIM : 602215
UniProt ID : O15263
Chromosome Location : 8p23.1-p22

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